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Miss S., aged 30, of good family and personal history, was attacked with typhoid lever Oct. 6, 1900, and the disease pursued a mild and favorable course until October 20, when she was seized with agonizing pain in the abdomen accompanied by severe shock. I saw her half an hour later and found her temperature 96, pulse 150, skin cold and wet and altogether presenting the symptoms of perforation. The nurse had given a hypodermic injection of morphin ¼ grain, and strychnin 1/20 grain. Dr. J. H. Duncan saw the patient with me and we deemed it inexpedient to operate on account of her desperate condition. The strychnin and morphin were repeated at varying intervals to control the pain and sustain the heart, and normal salt solution was transfused beneath the skin every 12 hours, a quart being used each time. Tympanitis, which had been absent, soon became excessive,
HOLMES TK. TYPHOID FEVER WITH PERFORATION OF THE BOWEL AND RECOVERY.. JAMA. 1903;XL(11):714-715. doi:10.1001/jama.1903.92490110030001f