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Article
March 14, 1903

THE LIMITATIONS OF THE CYTOTOXIC THEORY.

JAMA. 1903;XL(11):716-717. doi:10.1001/jama.1903.02490110032004

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Abstract

Just now the cytotoxin occupies the center plank of the stage of medical research. The antitoxin is ancient history, and even the hemolysin and the bacteriolysin are falling behind. There is probably no organ or tissue that is not now being injected in emulsionized form into the midst of the complacent goat, the sedate goose, the rabbit or guinea-pig. We may look soon for a deluge of reports on cytotoxin work, and we should await them with interest, for present indications are that the results may be either very great or very small. It is the simplicity of method that undoubtedly accounts for the rapid and general invasion of the field. One simply takes some particular organ or tissue, preferably one not already studied, grinds it up with sand and aseptic precautions, extracts it with salt solution, and injects the product into the selected animal. After a number of such

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