March 21, 1903


Author Affiliations

From the William Pepper Clinical Laboratory (Phoebe A. Hearst Foundation), and the Laboratory of the Pennsylvania Live Stock Sanitary Board. PHILADELPHIA.

JAMA. 1903;XL(12):753-756. doi:10.1001/jama.1903.92490120001001a

The usual text-book descriptions of hydrophobia give a clinical course of the disease divided into three stages. It is, however, difficult in practice to separate the clinical manifestations by any fixed rule.

The incubation period is usually about six weeks. In both the cases reported in this paper it was about that length. The onset of the disease is marked by several days of malaise, with slight fever, anxiety and, in a large number of cases, irritation at the seat of the infecting wound. The temperature at this stage is usually elevated one or two degrees, although it may remain at normal. This stage of irritation soon passes over to the convulsive stage. In some cases there is no convulsion or spasm, and the premonitory stage is followed by the paralytic symptoms. The symptoms of the second stage begin with more or less difficulty in the act of swallowing. Anything

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