[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.167.149.128. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 28, 1903

THE ADMINISTRATION OF CALCIUM SALTS IN NEPHROLITHIASIS DUE TO URIC ACID CALCULI.

Author Affiliations

PROFESSOR OF MEDICINE, POST-GRADUATE MEDICAL COLLEGE. CHICAGO.

JAMA. 1903;XL(13):818-820. doi:10.1001/jama.1903.92490130002001a
Abstract

THE UNDERLYING FACTS AND PRINCIPLES.  Phosphoric acid forms three salts with sodium, as follows :H3PO4, phosphoric acid.NaH2PO4, mono-sodium-phosphate.Na2HPO4, di-sodium-phosphate.Na3PO4, tri-sodium-phosphate.The mono- and the di-sodium phosphate normally occur in the urine. Uric acid is readily soluble in di-sodium phosphate, but it is not soluble in mono-sodium phosphate. The addition, in fact, of mono-sodium phosphate to a solution of uric acid in di-sodium phosphate will cause the precipitation of the uric acid.It is clear, therefore, that the solubility of uric acid in the urine is enhanced by the presence of di-sodium phosphate and that the tendency to the formation of uric acid concretions increases in proportion to the amount of mono-sodium phosphate that is excreted through the kidneys.It is also clear that any endeavor directed toward preventing the precipitation of uric acid in the urinary passages must be concerned with increasing the amount of

First Page Preview View Large
First page PDF preview
First page PDF preview
×