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March 28, 1903


Author Affiliations

Department of Physiology, Northwestern University Medical School. CHICAGO.

JAMA. 1903;XL(13):834-838. doi:10.1001/jama.1903.92490130018001d

INTRODUCTION.  In 1777 Lavoissier showed that oxygen was absorbed from air during respiration and that it united with carbon in the body, forming carbon dioxid. This discovery caused many observers to determine the amount of oxygen consumed by normal animals and the amount of carbon dioxid given off by them. They also studied the relation of one to the other. When we consider the volume of carbon dioxid exhaled divided by the volume of oxygen consumed, this relation is known as the respiratory quotient. Generally more oxygen is consumed than carbon dioxid given off.The object of these experiments was to determine the influence of tuberculosis on the respiratory quotient. A number of secondary facts have been established or confirmed, incidentally

METHODS.  Some of the early experimenters (Black, Priestly and LaPlace) analyzed the air of a chamber before and after an animal had been confined in it. the objection to this

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