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In this paper the term vaccine is used in the restricted sense, meaning smallpox vaccine. The purchases of vaccine by the Chicago Department of Health have been subject to inspection and test of each lot received since 1894. During July, 1894, an extended investigation of vaccine was made and showed that glycerinated lymph contained fewer bacteria and had a longer period of efficiency than the dry vaccine points. Glycerinated vaccine was therefore introduced and has been used exclusively ever since. The exact date of the first distributions was Aug. 1, 1894. The points herein brought out are consequently based on the inspection of this supply of the glycerinated product. There have been distributed to the vaccinators approximately one million individual vaccinations from that date to this. Some 20,000 tubes have been used for the purpose of testing; 10,000 for the bacteriologic and animal experiments and 10,000 for the clinical
GEHRMANN A. LABORATORY INSPECTION OF VACCINE.. JAMA. 1903;XL(17):1144–1145. doi:10.1001/jama.1903.92490170025002h