Author Affiliations: Cardiovascular Division, Department of Medicine II, Kansai Medical University, Hirakata, Japan (Dr Miyasaka); and Division of Cardiology, University of British Columbia, Vancouver, Canada (Dr Tsang).
In this issue of JAMA, the report by Conen and colleagues1 provides further evidence to confirm an increased mortality risk among middle-aged women with new-onset atrial fibrillation (AF). The study cohort consisted of 34 722 health care professionals in the Women's Health Study (WHS) who agreed to prospective follow-up after the end of the randomized treatment trial. These women were aged 49 to 59 years and free of cardiovascular disease at baseline. During a median follow-up of 15.4 years, 1011 women (2.9%) developed new-onset AF, and 63 deaths occurred among these women. In multivariable models, incident AF was associated with an increased adjusted risk of all-cause mortality, as well as cardiovascular and noncardiovascular death.
Miyasaka Y, Tsang TSM. Mortality Risk Among Middle-aged Women With First Atrial Fibrillation. JAMA. 2011;305(20):2116-2117. doi:10.1001/jama.2011.699