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February 1, 2012

Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587.

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Computational Biology and Bioinformatics (Mr Acharya) and Department of Statistical Sciences (Dr Mukherjee), Duke University, Durham, North Carolina; Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina (Drs Mukherjee, Dressman, Ginsburg, Garman, and Nevins) (; Departments of Medicine (Drs Hsu, Marcom, Ginsburg, and Garman) and Biostatistics and Bioinformatics (Dr Barry), Hematology-Oncology Associates (Dr Tuchman), and Durham Veterans Affairs Medical Center (Dr Moylan), Duke University Medical Center, Durham, North Carolina; University of North Carolina Lineberger Cancer Center, Chapel Hill (Dr Anders); DCH Cancer Center, Medical Oncology, Tuscaloosa, Alabama (Dr Anguiano); University of North Carolina, Chapel Hill (Ms Salter); Department of Toxicology, North Carolina State University, Raleigh (Ms Walters); Pulmonary and Critical Care Medicine, South Sound Pulmonary Associates, Olympia, Washington (Dr Redman); Department of Medicine, Duke University School of Medicine, Duke Cancer Institute, Durham, North Carolina (Dr Lyman); and Coastal Cancer Center, Myrtle Beach, South Carolina (Dr Potti).

JAMA. 2012;307(5):453. doi:10.1001/jama.2012.2

To the Editor: We would like to retract the article entitled “Gene Expression Signatures, Clinicopathological Features, and Individualized Therapy in Breast Cancer,” which was published in the April 2, 2008, issue of JAMA.1 A component of this article reported the use of chemotherapy sensitivity predictions based on an approach described by Potti et al in Nature Medicine in 2006. The Nature Medicine article was recently retracted due to an inability to reproduce the results with the chemotherapy signatures.2 Because a significant component of this JAMA article was based on the use of chemotherapy signatures reported in the Nature Medicine paper, we have decided to retract the JAMA article. We apologize for any negative impact on scientific research or clinical care caused by the publication of our article in JAMA.

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Article Information

Published Online: January 6, 2012. doi:10.1001/jama.2012.2.

Acharya CR, Hsu DS, Anders CK,  et al.  Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer.  JAMA. 2008;299(13):1574-1587PubMedArticle
Potti A, Dressman HK, Bild A,  et al.  Retraction: Genomic signatures to guide the use of chemotherapeutics.  Nat Med. 2011;17(1):135PubMedArticle