Demographics indicates age, year of diagnosis, and Surveillance, Epidemiology and End Results site; presentation indicates demographics variables plus comorbid conditions and tumor characteristics (stage, tumor size, tumor grade, and estrogen receptor status); treatment indicates presentation variables plus details of surgery, radiation, and chemotherapy. The extent of the difference between black patients and white patients is the vertical distance between the black and demographics-matched white curves.
The overall survival difference did not change (blacks and demographics-matched whites each started with N = 2832 in the pretaxane era and N = 2419 in the post-taxane era).
Silber JH, Rosenbaum PR, Clark AS, Giantonio BJ, Ross RN, Teng Y, Wang M, Niknam BA, Ludwig JM, Wang W, Even-Shoshan O, Fox KR. Characteristics Associated With Differences in Survival Among Black and White Women With Breast Cancer. JAMA. 2013;310(4):389-397. doi:10.1001/jama.2013.8272
Difference in breast cancer survival by race is a recognized problem among Medicare beneficiaries.
To determine if racial disparity in breast cancer survival is primarily attributable to differences in presentation characteristics at diagnosis or subsequent treatment.
Design, Setting, and Patients
Comparison of 7375 black women 65 years and older diagnosed between 1991 to 2005 and 3 sets of 7375 matched white control patients selected from 99 898 white potential controls, using data for 16 US Surveillance, Epidemiology and End Results (SEER) sites in the SEER-Medicare database. All patients received follow-up through December 31, 2009, and the black case patients were matched to 3 white control populations on demographics (age, year of diagnosis, and SEER site), presentation (demographics variables plus patient comorbid conditions and tumor characteristics such as stage, size, grade, and estrogen receptor status), and treatment (presentation variables plus details of surgery, radiation therapy, and chemotherapy).
Main Outcomes and Measures
The absolute difference in 5-year survival (blacks, 55.9%; whites, 68.8%) was 12.9% (95% CI, 11.5%-14.5%; P < .001) in the demographics match. This difference remained unchanged between 1991 and 2005. After matching on presentation characteristics, the absolute difference in 5-year survival was 4.4% (95% CI, 2.8%-5.8%; P < .001) and was 3.6% (95% CI, 2.3%-4.9%; P < .001) lower for blacks than for whites matched also on treatment. In the presentation match, fewer blacks received treatment (87.4% vs 91.8%; P < .001), time from diagnosis to treatment was longer (29.2 vs 22.8 days; P < .001), use of anthracyclines and taxols was lower (3.7% vs 5.0%; P < .001), and breast-conserving surgery without other treatment was more frequent (8.2% vs 7.3%; P = .04). Nevertheless, differences in survival associated with treatment differences accounted for only 0.81% of the 12.9% survival difference.
Conclusions and Relevance
In the SEER-Medicare database, differences in breast cancer survival between black and white women did not substantially change among women diagnosed between 1991 and 2005. These differences in survival appear primarily related to presentation characteristics at diagnosis rather than treatment differences.
For 20 years health care investigators in United States have been keenly aware of racial disparities in survival among women with breast cancer.1- 4 Numerous reports have not only identified and documented worse outcomes in black patients with breast cancer5- 7 but have suggested potential reasons for the disparities based on differences in screening,5,8,9 presentation,5,10 comorbid conditions on presentation,5,10 tumor biology,5,11,12 stage,5,6 treatment,5,13,14 and socioeconomic status.7,15
This study examined the extent of the racial disparity in breast cancer survival in the Medicare population, with the main goal of addressing why the disparity exists. The analysis used matching to compare the entire population of blacks in the Surveillance, Epidemiology and End Results (SEER)–Medicare database to 3 white populations individually paired to the black population to answer questions about the origins of the racial disparity, specifically, (1) are white women who present like black women treated in the same way as black patients, and if not, (2) to what extent does a difference in treatment explain the disparity in survival?
This study also examined the magnitude of the disparity; whether the disparity changed between the era before introduction of taxanes (1991-1998) and the era after introduction of taxanes (1999-2005); the relative contributions of presentation at diagnosis, and treatment after presentation, to differences in survival experienced by these groups; and how socioeconomic variables relate to the overall disparity.
The research protocol was approved by the institutional review board of The Children’s Hospital of Philadelphia. We obtained the SEER-Medicare database for the years 1991-2005 for 16 SEER sites throughout the United States. For each patient, the entire SEER data set16,17 was merged with Medicare Part A, Part B, outpatient claims, and the Social Security denominator file, which was updated December 31, 2009, for this data set, providing a minimum of 4 years of follow-up for all patients.
For all analyses of trends over time, we analyzed the 12 SEER sites collecting data over the entire span of the study. For analyses not considering trends over time, we used all 16 sites.
We defined race using the SEER algorithm18 and compared black or African American with white non-Hispanic and white-Hispanic together for the primary analysis (results were similar if only non-Hispanic white patients were used as controls, because Hispanic white patients comprised only 3.8% of the total white population and because never more than 4.6% of any set of matched pairs included Hispanic whites). Patient comorbid conditions such as congestive heart failure, diabetes, past acute myocardial infarction, stroke, hypertension, and 21 other conditions noted in the eAppendix (Supplement) were defined with International Classification of Diseases, Ninth Revision, Clinical Modification codes19- 22 and collected from Medicare claims (inpatient, outpatient, and physician bills) during a 3-month period prior to diagnosis.
Patient tumor characteristics, including stage, size, grade, estrogen receptor status, number of nodes dissected, and number of positive nodes, were obtained through the SEER database.
We defined treatment based on information from Medicare and SEER data. Surgery and chemotherapy were defined by billing codes in the Medicare claims; surgery was classified into conserving and nonconserving surgery types. Radiation therapy was determined by billing codes and SEER data. All definitions are provided in the eAppendix (Supplement).
We included all black patients for each match, so the black study population was constant and fully representative of black patients in the SEER population. The white population changed according to the variables used in the match. We created 3 matched analyses, each using 1 white patient and 1 black patient in each matched pair. The demographics analysis matched white to black patients on age, year of diagnosis, and SEER site; the presentation analysis matched pairs of black and white patients on the demographics variables as well as presentation characteristics (comorbid conditions and tumor biology [stage, size, grade, and estrogen receptor status]); and the treatment analysis matched patients on demographics and presentation variables as well as relevant treatment variables such as surgery, radiation therapy, and chemotherapy, as well as individual types of surgery and chemotherapy.
As has been suggested by Rubin,23- 25 matching was performed first, without viewing outcomes. All matching was implemented using the PROC ASSIGN26 function in SAS, providing optimal matches that minimize the distance between cases and controls.27 We used near-fine balance for SEER site in the treatment match.28- 30 This meant that matches were geographically balanced, with each SEER site contributing almost identical numbers of white and black patients (eAppendix [Supplement]).
Matching on patient covariates in the presentation and treatment matches also included a score predicting black race (a propensity score), and a risk score based on a Charlson score.31- 34 The propensity scores used for the matches came from a logistic regression of black vs white race on the variables to be controlled in the match (eAppendix [Supplement]). Matching on a propensity score tends to balance variables in the score.27,35,36
For each matching variable we verified that the match balanced the variables it intended to balance. We examined the standardized difference for each matching variable, which is the mean difference between black and white as a fraction of the standard deviation (SD) before matching.20,37,38We aimed to achieve standardized differences below 0.1 SDs.20,27,37,38 We also assessed how closely we achieved balance using 2-sample randomization tests, specifically the Wilcoxon rank-sum test for each continuous covariate, Fisher exact test for each binary covariate, and a single cross-match test for all covariates in a given match.39 The cross-match test estimates a summary measure, upsilon (Υ) (range, 0-1), that compares the actual match to the balance obtained by complete randomization. Υ = 0.5 suggests that the match resembled a randomized trial, indicating a successful match, whereas Υ = 0 signifies that the covariates always could be used to perfectly separate black patients from white patients—ie, a totally unsuccessful match—and Υ > 0.5 signifies better balance on observed covariates than expected by randomization.
When testing the hypothesis of no difference in outcomes between the matched black and white patients, the Wilcoxon sign-rank statistic40 was used for continuous outcomes, the McNemar statistic41 for binary outcomes, and the Prentice-Wilcoxon statistic42,43 for survival outcomes. When modeling survival differences over time, we used the paired version of the Cox proportional hazards model.44 We obtained standard errors for the white-black paired differences in survival utilizing the bootstrap method.45 White-to-white comparisons were made using the same methods applied to the exterior match of nonoverlapping white control groups.42,43,46P ≤ .05 (2-tailed) was considered statistically significant. All tests were performed using SAS version 9.2 for UNIX (SAS Institute Inc)47 or R version 18.104.22.168
A total of 107 273 patients were newly diagnosed with invasive breast cancer over all 16 sites, including 7375 black patients and 99 898 white patients from whom control patients were matched. Table 1 reports the total black population and 3 white populations matched sequentially to the black population.
The 3 matched white groups sequentially remove aspects of the disparity while leaving other aspects in place so as to develop an understanding of how the disparity occurs. In each match, the variables controlled in that match were closely balanced, with no standardized difference ever exceeding 0.09 SDs. In a given match, unmatched variables exhibit differences that reveal aspects of the disparity. For example, among all black patients with breast cancer, 26% had a diagnosis of diabetes, whereas whites matched for age, year of diagnosis, and SEER site had a much lower rate of diabetes (15.3%). The presentation match then removed the difference in diabetes and many other characteristics describing patients at the time of cancer diagnosis; eg, in the presentation match, 25.9% of whites had diabetes, similar to the rate among blacks. The treatment match also identified whites with a similar rate of diabetes as blacks but also controlled for cancer treatment. Similar matching results for tumor biology and treatment variables were also achieved.
We checked the simultaneous balance of all matched covariates using the cross-match test and its summary measure Υ.39,49 For each match, the multivariate imbalance in matched covariates was smaller than expected by random assignment to groups (P > .99, Υ = 0.98 for demographics; P > .99, Υ = 0.65 for presentation; P > .99, Υ = 0.53 for treatment). Thus, in each matched sample, using the matched covariates to identify black and white patients performed no better than chance.
Table 1 also reports information on differences in treatment by race. Overall, 12.6% of black patients did not have evidence of receiving any treatment for their breast cancer, compared with 5.9% of whites (P < .001, black patients vs demographics-matched white patients). However, even among whites who presented with the same patient and tumor characteristics as blacks, 8.2% did not have evidence of treatment (P < .001, blacks vs presentation-matched whites). Similarly, among those who did receive treatment, mean time from diagnosis to treatment was longer among blacks than among demographics-matched whites, 29.2 days vs 22.5 days (P < .001), and even among whites who presented like blacks, the delay was 22.8 days (P < .001). Blacks were also more likely to have very long delays in treatment. Whereas 5.8% of blacks did not initiate treatment within the first 3 months from diagnosis, only 2.5% of whites who presented like blacks displayed this gap (P < .001). Chemotherapy was also different for blacks and whites: 3.7% of blacks received both an anthracycline and a taxane, compared with 5.0% of whites matched to blacks at presentation (P < .001). Blacks also received breast-conserving surgery without any other treatment more often than presentation-matched whites (8.2% vs 7.3%, P = .04).
Figure 1 shows the survival of black patients and the corresponding white matched pairs for all 16 SEER sites in patients diagnosed with breast cancer between 1991 and 2005. Median follow-up time after diagnosis for censored patients was 7.6 years (interquartile range [IQR], 5.7-10.1) for blacks; 7.8 years (IQR, 5.8-10.5) for demographics-matched whites; 7.7 years (IQR, 5.8-10.4) for presentation-matched whites; and 7.6 years (IQR, 5.6-10.2) for treatment-matched whites. Table 2 reports the 2- and 5-year survival differences, and median survival time, for the black and matched white populations. The absolute survival difference between blacks and demographics-matched whites at 5 years was 12.9% (P < .001).
Figure 1 also shows the white presentation match, representing white patients who had the age, year of diagnosis, and SEER site variables in the match but who also were matched on patient characteristics including comorbid conditions and tumor characteristics, including, but not limited to, stage, size, grade, and estrogen receptor status. The absolute difference in 5-year survival between the presentation-matched white population and the black total population was 4.4% (P < .001).
We also observed the treatment-matched white population, controlling all the variables in the presentation match as well as specific treatments including type of surgery, radiation therapy, and chemotherapy. The absolute difference in 5-year survival between the treatment-matched white population and the total black population was 3.6% (P < .001). Comparing the 5-year survival for whites who presented like blacks (ie, the whites matched to blacks on presentation and demographic variables) with whites who presented and were treated like blacks (ie, the whites matched to blacks on presentation and demographic variables as well as treatment variables), the absolute difference was small (0.81%) but statistically significant (P = .04). We further examined the causes of death determined by SEER based on death certificates for the treatment-matched pairs (eAppendix [Supplement]). Overall, about half of the deaths at 5 years were cancer related. Furthermore, about two-thirds of the difference in 5-year mortality between black and white patients was attributable to cancer-related causes, and one-third to noncancer causes of death.
Figure 2 shows survival of all black patients and demographics-matched white patients in pairs of patients diagnosed in the era before the introduction of taxanes (pretaxanes; 1991-1998) and in the era after the introduction of taxanes (posttaxanes; 1999-2005) for just the 12 SEER sites that collected data in both periods. Both black and matched white survival improved slightly between eras, but the change in the black-white difference was small and not significantly different from zero (12.4% in the pretaxanes period and 12.2% in the posttaxanes period; P = .65). There also was no significant difference in the difference between blacks and whites matched on presentation or the treatment match between the eras before and after introduction of taxanes (eAppendix [Supplement]).
There were large differences in the way black and white patients presented. As a secondary analysis we studied differences in primary care well before diagnosis occurred in black and matched white populations. Table 3 describes preventive care indicators between 18 months to 6 months prior to diagnosis of breast cancer in the study’s 3 matched pairs. (See eAppendix [Supplement] for coding definitions.) For the demographics match, blacks had significantly less evidence of at least 1 primary care visit50,51 than matched whites (80.5% vs 88.5%, respectively; P < .001); significantly lower rates of breast cancer screening (23.5% vs 35.7%; P < .001); and significantly lower rates of colon cancer and cholesterol screening. Smaller differences, still significant, were observed for presentation and treatment matches.
In this analysis we have reported the demographics match using only age, SEER site, and year of diagnosis that served as our base case for which we compared the role of presentation and then treatment. Because presentation comprises some variables that are potentially changeable (such as comorbid conditions and tumor size at time of diagnosis) and some that are biological and should not change (such as estrogen receptor status), we also present a secondary matching analysis that included the demographics matching variables plus estrogen receptor status (eAppendix [Supplement]). We found that 5-year survival in white patients matched to black patients for demographics plus estrogen receptor status decreased from 68.8% (95% CI, 67.8%-69.9%) to 67.1% (95% CI, 66.0%-68.1%) (P < .001). Hence, a portion of the survival difference between the demographics match and the presentation match was due to differences in estrogen receptor status, and as such should not be something that better screening or primary care could directly change, although improved preventive measures may potentially allow for earlier diagnosis.
As a final secondary analysis, using the treatment-matched pairs, we fit a paired Cox model to evaluate the influence of race before and after adjusting for dual eligibility status for both Medicare and Medicaid. Without adjustment, the black-vs-white hazard ratio for death was 1.11 (95% CI, 1.05-1.17) (P < .001). After adjusting for dual eligibility status, the hazard ratio was 1.02 (95% CI, 0.97-1.09) (P = .41). Using variables reflecting neighborhood poverty and education (Census 2000, databased on the patient’s census tract) we observed findings similar to those obtained by adjusting for dual eligibility (eAppendix [Supplement]).
The large racial difference in breast cancer survival from diagnosis did not change between 1991-1998 and 1999-2005. Most of the difference is explained by poorer health of black patients at diagnosis, with more advanced disease, worse biological features of the disease, and more comorbid conditions. The 5-year survival difference observed with whites matched for demographics (age, year of presentation, and SEER site) was 12.9%, or a difference in median survival time of nearly 3 years, whereas with whites matched for cancer and comorbid conditions (ie, the presentation match) the difference was 4.4%, or a median survival difference of less than 1 year. Compared with whites who both presented like blacks and were treated like blacks, (ie, the treatment match), the difference only changed by 3.6%; hence, treatment differences explained only 0.81% of the 12.9% difference in 5-year survival. Treatment disparities might matter more if blacks were diagnosed with less advanced cancers.
The 3.6% remaining racial difference in 5-year survival after matching on treatment was predominantly cancer related (eAppendix [Supplement]). However, given that racial and income disparities are seen throughout the US health care system,52 it would have been surprising to observe a complete elimination of the survival difference by matching for similar cancer presentation and treatment.
One important strength of our study was that 99 898 white patients were used as potential controls for 7375 black patients. This allowed us to achieve very close matches, generally avoiding the need for model-based analyses. A model fitted to 99 898 whites and 7375 blacks would be a model that mostly describes what happens to whites.53
There were important limitations to this study. We did not have chart review to verify our definitions of treatment coded from Medicare bills or noted in SEER data. Hence, for example, we could not track the use of tamoxifen, although other studies have suggested that black patients use tamoxifen in at least as high a rate as white patients when they have estrogen receptor–positive tumors.54- 57 Nevertheless, it is possible that some portion of the residual unexplained difference after accounting for presentation and treatment relates to endocrine therapy not tracked in SEER. Furthermore, using SEER data we could not define triple-negative tumors.58 However, triple-negative tumors are less common in postmenopausal than premenopausal blacks (14% vs 39%), and postmenopausal blacks and whites display no difference in their rates of triple-negative tumors.58
Our results suggest that it may be difficult to eliminate the racial disparity in survival from diagnosis unless differences in presentation can be reduced. There is also a disparity in treatment, with blacks receiving treatment inferior to that received by whites with similar presentation, but this explains only a small part of the observed difference in survival. The disparity in treatment might matter more if the disparity in presentation were reduced, because blacks would then be diagnosed with less advanced disease, for which treatment is more effective.
Whether better screening for breast cancer would reduce the disparity in presentation is not known. Our data provide evidence suggesting that black patients diagnosed with breast cancer had previously received less adequate primary care than did white patients in the demographics match. Also, blacks were diagnosed with more advanced-stage disease and also with larger tumors. If a woman has limited primary care, then apart from screening, it may take longer before she seeks medical attention for a lump in her breast. Our data cannot distinguish the effects of screening from the effects of greater access to primary care. Screening and earlier diagnosis might be ineffective if black patients and white patients with similar cancer biology as measured by SEER had very different cancer biology if measured in much greater detail; however, in our population of elderly Medicare patients, differences in biology are smaller issues than in premenopausal patients.
Black patients are diagnosed not only with more advanced breast cancers but also with more unrelated comorbid conditions. Some of the effectiveness of cancer treatment for blacks may be blunted by other health problems. If the differences in comorbid conditions at diagnosis were reduced, it is possible that the differences in cancer treatment would matter more for the differences in survival.
In the SEER-Medicare database, racial differences in breast cancer survival did not substantially change among women diagnosed between 1991 and 2005. These differences in survival appear primarily related to presentation characteristics at diagnosis rather than treatment differences. In the presence of large racial differences in patient characteristics at presentation, treatment differences explained only a small portion of the survival difference, because white women who presented like black women (ie, were matched on demographics and presentation) but who received treatment similar to that received by white women fared almost the same as white women who presented like black women and who were treated in the same way as black women.
Corresponding Author: Jeffrey H. Silber, MD, PhD, Center for Outcomes Research, The Children’s Hospital of Philadelphia, 3535 Market St, Ste 1029, Philadelphia, PA 19104 (firstname.lastname@example.org).
Author Contributions: Dr Silber had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Silber, Rosenbaum, Clark, Giantonio, Fox.
Acquisition of data: Silber, Even-Shoshan, Fox.
Analysis and interpretation of data: Silber, Rosenbaum, Clark, Ross, Teng, M. Wang, Niknam, Ludwig, W. Wang, Fox.
Drafting of the manuscript: Silber, Rosenbaum, Clark, Ross.
Critical revision of the manuscript for important intellectual content: Silber, Rosenbaum, Clark, Giantonio, Teng, M. Wang, Niknam, Ludwig, W. Wang, Even-Shoshan, Fox.
Statistical analysis: Silber, Rosenbaum, Ross, Teng, Ludwig, W. Wang.
Obtained funding: Silber, Rosenbaum, Even-Shoshan.
Administrative, technical, or material support: Clark, M. Wang, Niknam, Even-Shoshan.
Study supervision: Silber, Rosenbaum, Even-Shoshan, Fox.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This research was funded through a grant from the Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services (R01 HS 018355), and by the US National Science Foundation (NSF SBS 1260782). This study used the linked SEER-Medicare database.
Role of the Sponsor: The AHRQ and the US National Science Foundation had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
Disclaimer: The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the AHRQ.
Additional Contributions: We thank Traci Frank, AA, Hong Zhou, MS, Philip Saynisch, BA, and Alexander Hill, BS (Center for Outcomes Research, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania), for their assistance with this research. None of these individuals received compensation apart from salary for their contributions. We also acknowledge the efforts of the Applied Research Program, National Cancer Institute; the Office of Research, Development and Information, Centers for Medicare & Medicaid Services; Information Management Services Inc; and the Surveillance, Epidemiology and End Results (SEER) Program tumor registries in the creation of the SEER-Medicare database.