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In This Issue of JAMA
September 4, 2013

Highlights

JAMA. 2013;310(9):873. doi:10.1001/jama.2013.5286
Research

In a randomized trial of 2004 patients with or at risk of cardiovascular disease (CVD), Thom and colleagues found that compared with usual care, a fixed-dose combination medication containing aspirin, a statin, and 2 antihypertensive agents improved medication adherence, systolic blood pressure, and low-density lipoprotein cholesterol levels. In an Editorial, Gaziano discusses In an Editorial, Gaziano discusses challenges in the use of a combination “polypill” to reduce CVD risk.

Related Editorial

Author Video Interview, Continuing Medical Education

Spijkerman and colleagues randomly assigned 400 infants to receive the 13-valent pneumococcal conjugate vaccine (PCV) according to 1 of 4 different immunization schedules and found no difference in antibody levels for most serotypes at age 12 months. In an Editorial, O’Brien discusses optimal use of the PCV vaccine.

Related Editorial

There has been concern that provision of iron to children with iron deficiency in malaria-endemic areas may increase the malaria risk. In a cluster randomized trial involving 1958 rural Ghanaian children, Zlotkin and colleagues found that daily use of a micronutrient powder with iron did not increase the incidence of malaria. In an Editorial, Prentice and colleagues discuss iron fortification and malaria risk in children.

Related Editorial

Xu and colleagues analyzed data from a 2010 national sample of 98 658 Chinese adults and report estimated prevalences of diabetes and prediabetes of 11.6% and 50.1%, respectively. In an Editorial, Chan discusses control of preventable noncommunicable diseases in China.

Related Editorial

In an analysis of baseline data from 142 042 participants in the multinational Prospective Urban Rural Epidemiology Study Chow and collegues found 40.8% had hypertension. Among those diagnosed 46.% were aware of their diagnosis, 40.6% were receiving treatment, and blood pressure was controlled in 32% of threated individuals.

Clinical Review & Education

In this From the JAMA Network article, Darmstadt and Munar discuss behavioral change and community mobilization to reduce neonatal mortality in high-poverty areas.

An infant born at 36 weeks’ gestation by cesarean deliver developed a widespread vesicular rash shortly after birth. The mother denied a history of sexually transmitted infections, cold sores, or genital lesions. What would you do next.

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