Prednisolone or pentoxifylline is recommended for treatment of severe alcoholic hepatitis.
Whether combination therapy offers added benefit is not known. Mathurin and colleagues randomly
assigned 270 patients with biopsy-proven alcoholic hepatitis to 4 weeks’ treatment with either
a combination of prednisolone and pentoxifylline or prednisolone and placebo. The authors report
that treatment with pentoxifylline and prednisolone, compared with prednisolone alone, did not
result in improved 6-month survival. In an Editorial, Halegoua-De Marzio and Fenkel discuss
treatment of severe alcoholic hepatitis.
Continuing Medical Education
To examine the effect of financial incentives to reward guideline-recommended hypertensive care,
Petersen and colleagues randomly assigned 12 Veterans Affairs hospital-based outpatient clinics
(staffed by 83 physicians and 42 nonphysician personnel) to receive physician-level (individual)
incentives; practice-level incentives; individual- and practice-level incentives; or no incentives
(controls). The authors report that individual incentives, but not practice-level incentives or a
combination of individual and practice-level incentives, resulted in greater blood pressure control
and appropriate response to uncontrolled blood pressure. Compared with controls, none of the
incentives resulted in greater use of guideline-recommended medications or increased the incidence
of hypotension. In an Editorial, Dolor and Schulman discuss the financial incentives in primary care
practice and achievement of population health goals.
Related Editorial, Related Article
The effect of pay-for-performance (P4P) in small physician practices is largely unknown, and the
relationship of electronic health records (EHRs) with chronic disease management capabilities to the
small-practice response to P4P has not been explored. In a cluster-randomized trial that involved 84
small (<10 physicians) primary care practices in New York City—all of which had the same
EHR and access to quality improvement specialists—Bardach and colleagues found that compared
with control practices, those randomly assigned to a P4P incentive program achieved modest
improvements in cardiovascular care processes and outcomes.
Use of electronic health records (EHRs) is assumed to have beneficial effects on patient health
outcomes or health care use, but evidence to support this assumption is limited. Reed and colleagues
examined the association between implementing an outpatient EHR and emergency department (ED)
visits, hospitalizations, and office visits in a population-based sample of 169 711 patients with
diabetes who received care in an integrated delivery system. In a before and after implementation
comparison, the authors found that use of an outpatient EHR was associated with modest reductions in
rates of ED visits and hospitalizations but not office visits.
Some data suggest that selective serotonin reuptake inhibitors (SSRIs) might improve recovery
after stroke. In this JAMA Clinical Evidence Synopsis, Mead and colleagues report results of a
systematic review and meta-analysis of data from 52 clinical trials (4059 participants) that
compared treatment with an SSRI—given at any dose or for any duration—with placebo or
usual care within the first year after a stroke. The authors examined the effect of SSRIs on
measures of dependency and disability at the end of treatment and the end of follow-up and found
that SSRIs may be associated with less dependence and disability after a stroke and less anxiety and
depression—even in patients who are not clinically depressed.
A patient with stage IV lung cancer developed erythematous follicular papules and pustules on the
scalp while undergoing treatment with an epidermal growth factor inhibitor. Potassium hydroxide
examination of the lesions was negative. What would you do next?
Highlights. JAMA. 2013;310(10):1001-1003. doi:10.1001/jama.2013.5299