Osteomyelitis is an inflammation of bone caused by an infecting organism. The infection may be limited to a single portion of the bone or may involve multiple areas. The infection is generally due to a single organism, but polymicrobial infections (caused by different and multiple bacteria or fungi) can occur,
especially in patients with diabetes. Persons of any age can develop a bone infection, although it is more common in children and persons older than 50 years. The February 20, 2008, issue of JAMA includes an article about the difficulties of identifying and diagnosing osteomyelitis in patients with diabetes.
Signs and symptoms of acute osteomyelitis in children typically worsen in a matter of days or weeks and may include
Pain, warmth, swelling, and redness over the area of infection
Signs and symptoms of chronic osteomyelitis in adults include
Warmth, swelling, and redness over the area of infection
Pain or tenderness in the affected area
Drainage from an open wound
Fever in some cases
Poor circulation—as in diabetes,
peripheral arterial disease, and sickle cell disease
Recent injury—a broken bone that breaks the skin or a deep puncture wound
Orthopedic surgery—procedures to repair broken bones or to replace worn joints
Other conditions—injection drug abuse,
kidney dialysis, use of a catheter
In addition to a medical history and physical examination,
a combination of tests and procedures may be used to diagnose osteomyelitis.
No single test can reliably exclude or confirm the diagnosis of osteomyelitis.
Blood tests—elevation of white blood cells and other factors may indicate an infection but blood tests may be normal in some patients.
X-rays—damage or loss of bone may not be visible until osteomyelitis has been present for several weeks.
Other imaging procedures—computed tomography (CT scan), magnetic resonance imaging (MRI), or bone scan
Bone biopsy—surgical removal of a small piece of infected bone for analysis in the laboratory.
Information regarding the type of infecting organism can help determine the best treatment, but bone biopsies are not performed in every patient.
Osteomyelitis is treated with appropriate antibiotics and surgery.
Surgical procedures may involve drainage of the infected area, removal of diseased bone and tissue, restoration of blood flow, or removal of foreign material.
American Association of Orthopaedic Surgeonshttp://www.orthoinfo.aaos.org
National Institute of Arthritis and Musculoskeletal and Skin Diseaseshttp://www.niams.nih.gov
To find this and previous JAMA Patient Pages, go to the Patient Page link on JAMA's Web site at http://www.jama.com. Many are available in English and Spanish.
Sources: American Association of Orthopaedic Surgeons, American Academy of Family Physicians, National Institute of Arthritis and Musculoskeletal and Skin Diseases
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Zeller JL, Burke AE, Glass RM. Osteomyelitis. JAMA. 2008;299(7):858. doi:10.1001/jama.299.7.858