Ventilator-associated pneumonia, defined as pneumonia (infection of the lung) occurring in a person who is being assisted by mechanical ventilation (a breathing machine), is a serious and life-threatening infection. Because individuals who contract ventilator-associated pneumonia are already critically ill (requiring mechanical ventilation), the death rate from ventilator-associated pneumonia is high. The August 20, 2008, issue of JAMA includes an article reporting that silver-coated endotracheal (breathing) tubes may help prevent ventilator-associated pneumonia. This Patient Page is based on one published in the April 11, 2007, issue of JAMA.
Longer duration of mechanical ventilation
Depressed level of consciousness
Preexisting lung disease
Immune suppression from disease or medication
Hand-washing procedures before and after any patient contact
Avoiding endotracheal intubation, if possible
Maintaining the bed at a 30-degree head-up position
Minimizing the duration of mechanical ventilation
Conversion to tracheostomy (hole in the throat) tube when ventilation is needed for a longer term
Proper endotracheal tube cuff pressures to prevent regurgitation of stomach contents
Enteral (through the intestinal tract) feedings instead of parenteral (through the veins) nutrition
Careful blood sugar control in patients with diabetes
Development of fever, increased white blood cell count, and new or changing lung infiltrate on chest x-ray are all signs of ventilator-associated pneumonia. Diagnosis can be challenging because other lung diseases can have similar signs and chest x-rays may not be conclusive. Cultures of tracheal aspirate (samples from the windpipe) show which bacteria (or fungus) are responsible for ventilator-associated pnuemonia. Sometimes bronchoscopy (looking directly at the trachea and bronchi with a special flexible lighted instrument) is necessary to get better samples. In rare cases, open lung biopsy to obtain lung tissue may be done.
Antibiotics remain the cornerstone of therapy for ventilator-associated pnuemonia. Choice of antibiotic is guided by bacteria culture results.
Because ventilator-associated pnuemonia occurs in hospitalized persons, it may be caused by bacteria that are resistant to multiple antibiotics. Treatment may require specialized antibiotics.
Supportive care, including prolonged mechanical ventilation and intensive care, may be necessary.
National Heart, Lung, and Blood Institutehttp://www.nhlbi.nih.gov
Centers for Disease Control and Preventionhttp://www.cdc.gov
American Lung Associationhttp://www.lungusa.org
To find this and previous JAMA Patient Pages, go to the Patient Page Index on JAMA's Web site at http://www.jama.com. Many are available in English and Spanish. A Patient Page on diagnosing and treating pneumonia was published in the February 9, 2000, issue.
Sources: National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; Society of Critical Care Medicine; American Lung Association
The JAMA Patient Page is a public service of JAMA. The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis. For specific information concerning your personal medical condition, JAMA suggests that you consult your physician. This page may be photocopied noncommercially by physicians and other health care professionals to share with patients. To purchase bulk reprints, call 312/464-0776.
TOPIC: LUNG DISEASES
Torpy JM, Lynm C, Glass RM. Ventilator-Associated Pneumonia. JAMA. 2008;300(7):864. doi:10.1001/jama.300.7.864