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JAMA Patient Page
August 20, 2008

Ventilator-Associated Pneumonia

JAMA. 2008;300(7):864. doi:10.1001/jama.300.7.864

Ventilator-associated pneumonia, defined as pneumonia (infection of the lung) occurring in a person who is being assisted by mechanical ventilation (a breathing machine), is a serious and life-threatening infection. Because individuals who contract ventilator-associated pneumonia are already critically ill (requiring mechanical ventilation), the death rate from ventilator-associated pneumonia is high. The August 20, 2008, issue of JAMA includes an article reporting that silver-coated endotracheal (breathing) tubes may help prevent ventilator-associated pneumonia. This Patient Page is based on one published in the April 11, 2007, issue of JAMA.


  • Longer duration of mechanical ventilation

  • Advanced age

  • Depressed level of consciousness

  • Preexisting lung disease

  • Immune suppression from disease or medication

  • Malnutrition


  • Hand-washing procedures before and after any patient contact

  • Avoiding endotracheal intubation, if possible

  • Maintaining the bed at a 30-degree head-up position

  • Minimizing the duration of mechanical ventilation

  • Conversion to tracheostomy (hole in the throat) tube when ventilation is needed for a longer term

  • Proper endotracheal tube cuff pressures to prevent regurgitation of stomach contents

  • Enteral (through the intestinal tract) feedings instead of parenteral (through the veins) nutrition

  • Careful blood sugar control in patients with diabetes


Development of fever, increased white blood cell count, and new or changing lung infiltrate on chest x-ray are all signs of ventilator-associated pneumonia. Diagnosis can be challenging because other lung diseases can have similar signs and chest x-rays may not be conclusive. Cultures of tracheal aspirate (samples from the windpipe) show which bacteria (or fungus) are responsible for ventilator-associated pnuemonia. Sometimes bronchoscopy (looking directly at the trachea and bronchi with a special flexible lighted instrument) is necessary to get better samples. In rare cases, open lung biopsy to obtain lung tissue may be done.


  • Antibiotics remain the cornerstone of therapy for ventilator-associated pnuemonia. Choice of antibiotic is guided by bacteria culture results.

  • Because ventilator-associated pnuemonia occurs in hospitalized persons, it may be caused by bacteria that are resistant to multiple antibiotics. Treatment may require specialized antibiotics.

  • Supportive care, including prolonged mechanical ventilation and intensive care, may be necessary.



To find this and previous JAMA Patient Pages, go to the Patient Page Index on JAMA's Web site at Many are available in English and Spanish. A Patient Page on diagnosing and treating pneumonia was published in the February 9, 2000, issue.

Sources: National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; Society of Critical Care Medicine; American Lung Association

The JAMA Patient Page is a public service of JAMA. The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis. For specific information concerning your personal medical condition, JAMA suggests that you consult your physician. This page may be photocopied noncommercially by physicians and other health care professionals to share with patients. To purchase bulk reprints, call 312/464-0776.