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August 5, 2009

Incorrect Wording in: Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis

JAMA. 2009;302(5):492. doi:10.1001/jama.302.5.492

Incorrect Wording: In the Review article titled “Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis” by Risch et al, published in the June 17, 2009, issue of JAMA (2009;301[23]:2462-2471), incorrect wording occurred. The third sentence of the “Analytic Methods” subsection on page 2464 should have read, “Second, we investigated the associations between stressful life events alone (entered as an ordinal variable) and the number of S alleles alone on depression as the response variable.” On page 2468, the last sentence of the first full paragraph of the first column should have read, “However, the meta-analysis yielded no significant differences in the β coefficients between those with and without depression across studies (β, −0.001; SE, 0.047) and sexes, indicating a lack of gene environment interaction.” And the second sentence in the second paragraph in the middle column of page 2469 should have read, “The most likely explanation for an interaction without a main effect would require a reversal in the direction of the life events-by-genotype association, with the risk of depression increasing with the number of S alleles in the presence of stressful life events and decreasing with the number S alleles in the absence of life events. Our analysis showed there was no such decrease.”