Blocking the cellular attachment of infecting
viruses is a promising research strategy for prevention of viral
illnesses. Turner and colleaguesArticle report that after experimental
rhinovirus infection, subjects who were treated for 7 days with
intranasal tremacamra, a recombinant soluble intercellular adhesion
molecule 1 (ICAM-1), had significantly lower symptom scores (Figure)
and lower nasal mucus weights and reported fewer colds than subjects
who received placebo. In an editorial, McIntoshArticle discusses key features
of prospective cures for the common cold.
Investigations of 2 outbreaks of multidrug-resistant
Salmonella Typhimurium DT104 infection in northern California
by Cody and coworkersArticle and of another outbreak in Washington State by
Villar and colleaguesArticle identified cheese made from unpasteurized milk as
the source of infection. In an editorial, KeeneArticle highlights the type of
information that is provided by investigations of disease outbreaks and
discusses the educational and regulatory efforts required to reduce the
incidence of foodborne illnesses.
Retrospective and cross-sectional studies suggest an
association between plasma homocysteine level and atherothrombotic
disease, whereas in prospective studies, an elevated homocysteine level
has not consistently been predictive of cardiovascular events. In this
prospective case-control study of 28,263 healthy postmenopausal
women in the Women's Health Study followed up for a mean of 3 years,
Ridker and colleagues found that women with elevated baseline
homocysteine levels were at increased risk of cardiovascular events,
especially those with the highest baseline levels. The increase in risk
associated with elevated homocysteine levels was moderate and less than
that associated with other previously identified cardiovascular disease
Anal squamous cell carcinoma may be preventable in high-risk
populations if precursor high-grade squamous intraepithelial lesions
are detected by routine screening. Based on estimates derived from a
model using a hypothetical cohort of homosexual and bisexual men
infected with the human immunodeficiency virus, Goldie and colleagues
conclude that routine screening with an anal Papanicolaou test would
prolong quality-adjusted life expectancy in this population at a cost
comparable with that of other preventive interventions.
In this review of trials of warfarin, aspirin, or both for the
prevention of stroke in patients with atrial fibrillation, Ezekowitz
and Levine suggest that optimal stroke prevention therapy may vary
depending on the coexistence of other risk factors. For persons older
than 65 years with other stroke risk factors, such as high blood
pressure, diabetes mellitus, or prior stroke, warfarin therapy was
associated with a much greater reduction in stroke risk than was
aspirin therapy. However, for patients between 65 and 75 years without
other stroke risk factors, aspirin therapy achieved a similar reduction
in stroke risk as warfarin.
"It is perfectly fine to glory in our successes, but we must
also confront our failures." From "Saying Good-bye."
The myriad ways in which the arts and the environment can
improve health and healing were discussed at the first World Symposium
on Culture, Health, and the Arts.
How to evaluate the usefulness of treatment recommendations.
Impact of US tobacco control legislation on smoking in
For your patients: Facts about Salmonella infection
from contaminated foods.
This Week in JAMA. JAMA. 1999;281(19):1773. doi:10.1001/jama.281.19.1773