The frequency of antibiotic use for the treatment of sore throat greatly
exceeds the prevalence of pharyngitis caused by group A β-hemolytic streptococci,
the only common cause of sore throat that warrants antibiotic treatment. In
this analysis of data from the National Ambulatory Medical Care survey, Linder
and Stafford found that antibiotics were prescribed by community primary care
physicians in 73% of the estimated 6.7 million annual visits for sore throat
in the United States between 1989 and 1999. Overall use of antibiotics for
sore throat decreased from 1989 to 1999, but treatment with broader-spectrum
Cardiovascular benefits of aspirin therapy have been demonstrated in
a variety of patient populations, particularly after acute myocardial infarction.
In this observational cohort study of clinically stable patients referred
for stress echocardiography, Gum and colleaguesArticle report that aspirin use was
independently associated with reduced long-term all-cause mortality during
a median follow-up of 3.1 years. In an editorial, Radford and FoodyArticle discuss
how observational studies may add to the results of randomized controlled
trials in the assessment of therapeutic interventions.
In previous reports, Mokdad and colleagues documented the increasing
prevalence of obesity and diabetes mellitus among adults in the United States
during the 1990s. Analysis of data from the Behavioral Risk Factor Surveillance
System in 2000 indicates that the prevalence of obesity and diabetes has continued
to increase nationwide. More than 56% of US adults are overweight, 19.8% are
obese, and 7.3% have diabetes.
Methicillin-resistant Staphylococcus aureus
(MRSA) infections have been acquired primarily in nosocomial settings, but
recent reports suggest that MRSA infections may also be community acquired.
Groom and colleagues conducted a retrospective cohort study to investigate
the occurrence of community-acquired MRSA infections in a rural midwestern
American Indian community in 1997. More than half of the S aureus isolates were MRSA, and most of the MRSA isolates were classified
as community acquired.
Sarcopenia, the decrease in muscle mass that occurs with aging, has
been attributed to a reduction in the rate of basal muscle protein synthesis.
In this study of basal muscle protein turnover in healthy young and older
men, however, Volpi and colleaguesArticle found that muscle protein synthesis was
slightly higher in older men, and basal net protein catabolism was not statistically
different. In an editorial, Roubenoff and CastanedaArticle suggest that sarcopenia
may be explained by the failure of aging muscle to respond to anabolic stimuli
rather than by a reduction in basal muscle protein synthesis rate.
"Mom and Tot classes and play groups are just two places where men receive
subtle messages regarding their expected role in child rearing. The physician's
office is another." From "Men's Work."
Monoclonal antibodies in the treatment of non-Hodgkin lymphoma.
President Bush's announcement that federally financed research may be
conducted on only 64 stem cell lines has scientists wondering about the quality
of the stem cell lines, their availability, and how useful they may prove
Kizer describes the National Quality Forum, an organization established
in 1999 to develop consensus about standardized health care performance measures,
reporting mechanisms, and a national strategy for health care quality improvement.
Systematic review of studies on the effect of exercise on glycemic control
and weight loss in patients with type 2 diabetes mellitus.
A joint statement from editors of general medical journals on the relationship
between investigators and sponsors in the conduct and reporting of biomedical
For your patients: Information about antibiotic resistance.
This Week in JAMA. JAMA. 2001;286(10):1141. doi:10.1001/jama.286.10.1141