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May 22/29, 2002

Three Errors in Medical News & Perspectives Article

JAMA. 2002;287(20):2656. doi:10.1001/jama.287.20.2656

The Medical News & Perspectives article entitled "Genome Analysis Yields Mutations Linked to Hereditary Prostate Cancer" in the February 20, 2002, issue of THE JOURNAL (2002;287:827-828) contained 3 errors in the second full paragraph on page 827. The article stated that Bryan R. G. Williams, PhD, had been studying the RNASEL gene for 10 years; in fact, his colleague at the Cleveland Clinic Foundation, Robert Silverman, PhD, led this work. The article also mistakenly stated that the protein product of the RNASEL gene is a tyrosine kinase that "signals cells to churn out inflammatory factors." In fact, the protein is not a tyrosine kinase; it is a ribonuclease for single-stranded RNA involved in the mechanism of action of interferon. Finally, the article cited a review by Williams (Oncogene. 1999;18:6112-6120); this review did not focus on RNase L, but rather on the interferon-regulated protein PKR.