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June 19, 2002

Placebo in Clinical Trials for Depression: Complexity and Necessity—Correction

JAMA. 2002;287(23):3083. doi:10.1001/jama.287.23.3083

Incorrect Wording. There was incorrect wording in the Editorial entitled "Placebo in Clinical Trials for Depression: Complexity and Necessity" published in the April 10, 2002, issue of THE JOURNAL (2002;287:1853-1854). The last 3 sentences in the fourth paragraph should read as follows: From this 8-week clinical trial, the authors conclude that neither sertraline nor hypericum was significantly different from placebo on either of the primary outcome measures: change in total Hamilton Depression Scale (HAM-D) score and full response defined by combined cut-off scores on both the HAM-D and the Clinical Global Impression Scale (CGI-I). However, sertraline was significantly better than placebo (P = .02) on the CGI-I alone, which was a secondary outcome measure in this study. The overall response rates (including partial and full response) were 38.1% for hypericum, 43.1% for placebo, and 48.6% for sertraline.