Major depressive disorder (MDD) is a risk factor for mortality after
acute myocardial infarction (MI), but only a minority of patients with depression
after an MI receive antidepressant treatment. In contrast to the cardiotoxic
effects of older antidepressants, Glassman and colleaguesArticle, for the Sertraline
Antidepressant Heart Attack Randomized Trial (SADHART) group, found that cardiovascular
safety outcomes among patients with MDD after hospitalization for acute MI
or unstable angina were not significantly different in the sertraline and
placebo groups. In an editorial, Carney and JaffeArticle discuss important directions
for future trials of treatment of depression following acute coronary syndromes.
Legislation has recently been introduced in 10 states and the US Congress
that would prohibit prescribed contraceptives for adolescents without parental
involvement. To determine the effect of mandatory parental notification for
precribed contraceptives on the use of sexual health services by adolescent
girls, Reddy and colleaguesArticle surveyed girls younger than 18 years seeking services
at Planned Parenthood family planning clinics in Wisconsin. More than half
of those surveyed indicated that they would stop using all sexual health care
services, delay testing or treatment for HIV or other sexually transmitted
diseases, or discontinue use of specific sexual health services if their parents
were informed that they were seeking prescribed contraceptives. In an editorial,
Ford and EnglishArticle discuss risks of limiting confidentiality of adolescent health services.
Graat and colleagues conducted a randomized controlled trial to evaluate
the effect of long-term daily multivitamin-mineral and vitamin E supplementation
on the incidence and severity of acute respiratory tract infection in elderly
individuals. The incidence of acute respiratory tract infection in the multivitamin-mineral,
multivitamin-mineral and vitamin E, and vitamin E alone supplementation groups
did not differ significantly from the incidence in the placebo group. Severity
of illness was worse in vitamin E vs no vitamin E groups.
Surgical site infections are among the leading nosocomial causes of
morbidity and a source of excess medical costs. In this randomized crossover
trial, Parienti and colleagues compared 30-day surgical site infection rates
using 2 hand-cleansing protocols for hand antisepsis before surgery—a
hand-rubbing cleansing protocol using an aqueous alcoholic solution and a
traditional hand-scrubbing protocol with an antiseptic preparation. Hand-rubbing
was as effective as hand-scrubbing in preventing surgical site infections.
Compliance with recommended duration of hand antisepsis was better and skin
dryness and irritation were less with the hand-rubbing protocol than with
the hand-scrubbing protocol.
Estimates of the effect of preterm birth on cognitive and behavioral
outcomes at school age are extremely variable. In this meta-analysis of case-control
studies of children born preterm that reported cognitive and/or behavioral
outcomes after age 5 years, Bhutta and colleagues found that preterm birth
was associated with lower cognitive scores and increased risks for attention-deficit/hyperactivity
disorder and other behavioral problems. Mean cognitive scores of preterm-born
cases and term-born controls were directly proportional to birth weight and
"The vanity of life lasts until death, whose arrival is certain but
almost always surprising. We all look for signs and hints, of change, of decline,
intimations of the end." From "Vanity."
At the XIV International AIDS Conference in Barcelona, delegates were
confronted with sobering news about the growing epidemic, some good and bad
news from biomedical researchers, and hopeful signs of a growing global commitment
to help poor nations cope with HIV/AIDS.
Three case studies illustrate how financial ties between tobacco and
pharmaceutical companies have created conflicts of interest that influence
the development and marketing of nicotine replacement therapies.
Childhood asthma: epidemiology, clinical course, and treatment.
Fontanarosa and DeAngelis denounce the recent break of the JAMA embargo
and discuss the rationale for THE JOURNAL's embargo policy.
In this meta-analysis of studies that evaluated the relationship between
physician gender and physician communication during medical visits, female
primary care physicians engaged in more patient-centered communication and
had longer visits than male physicians.
For your patients: Information about depression and the heart.
This Week in JAMA. JAMA. 2002;288(6):671. doi:10.1001/jama.288.6.671