Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB. Years of Life Lost Due to Obesity. JAMA. 2003;289(2):187-193. doi:10.1001/jama.289.2.187
Author Affiliations: Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Md (Dr Fontaine) and Department of Biostatistics (Drs Redden, Wang, and Allison and Mr Westfall), Section on Statistical Genetics, Clinical Nutrition Research Center (Drs Wang and Allison), University of Alabama, Birmingham.
Context Public health officials and organizations have disseminated health messages
regarding the dangers of obesity, but these have not produced the desired
Objective To estimate the expected number of years of life lost (YLL) due to overweight
and obesity across the life span of an adult.
Design, Setting, and Subjects Data from the (1) US Life Tables (1999); (2) Third National Health and
Nutrition Examination Survey (NHANES III; 1988-1994); and (3) First National
Health and Nutrition Epidemiologic Follow-up Study (NHANES I and II; 1971-1992)
and NHANES II Mortality Study (1976-1992) were used to derive YLL estimates
for adults aged 18 to 85 years. Body mass index (BMI) integer-defined categories
were used (ie, <17; 17 to <18; 18 to <19; 20 to <21; 21 to 45;
or ≥45). A BMI of 24 was used as the reference category.
Main Outcome Measure The difference between the number of years of life expected if an individual
were obese vs not obese, which was designated YLL.
Results Marked race and sex differences were observed in estimated YLL. Among
whites, a J- or U-shaped association was found between overweight or obesity
and YLL. The optimal BMI (associated with the least YLL or greatest longevity)
is approximately 23 to 25 for whites and 23 to 30 for blacks. For any given
degree of overweight, younger adults generally had greater YLL than did older
adults. The maximum YLL for white men aged 20 to 30 years with a severe level
of obesity (BMI >45) is 13 and is 8 for white women. For men, this could represent
a 22% reduction in expected remaining life span. Among black men and black
women older than 60 years, overweight and moderate obesity were generally
not associated with an increased YLL and only severe obesity resulted in YLL.
However, blacks at younger ages with severe levels of obesity had a maximum
YLL of 20 for men and 5 for women.
Conclusion Obesity appears to lessen life expectancy markedly, especially among
Many public health officials and organizations have tried to warn the
public about the dangers of obesity.1,2 One
of the strongest warnings came from the US surgeon General who stated that
a failure to address overweight and obesity "could wipe out some of the gains
we've made in areas such as heart disease, several forms of cancer, and other
chronic health problems."3
For a health message to be effective, it should be both understood by
the recipient and the information should be perceived as relevant.4 In trying to convey the magnitude of the deleterious
effects of obesity, investigators have presented information on the health
care costs due to obesity,5 the relative mortality
rates among obese vs nonobese persons,6 and
the number of annual deaths that might be attributable to obesity.7 These messages may not be effective for individuals
in the United States, who may be less interested in population-level effects.
One way to quantify the individual effect is in terms of the expected number
of years of life lost (YLL). The YLL is defined as
the difference between the number of years a person would be expected to live
if he/she was not obese and the number of years expected to live if the person
To our knowledge, only 1 study has attempted to calculate YLL estimates
due to obesity. Stevens et al8 found that YLL
estimates were greater for older than younger obese individuals. This seems
counterintuitive and may be the result of the investigators restricting their
analysis to a 12-year period rather than estimating YLL across the remaining
life span. This may have led to marked underestimation of YLL and may have
created a spurious positive correlation between baseline age and YLL. Therefore,
we conducted a study estimating YLL across the entire life span to provide
The YLL due to obesity can be estimated by combining 3 types of information1: an estimate of the distribution of body mass index
(BMI) for each year of adult life2; an estimate
of the hazard ratio (HR) for death given various BMI levels in each year of
adult life (ages 18-85 years); and the probability of death during each year
of adult life.3 Each of these types of information
was obtained from existing public use data sources. The steps used to calculate
YLL due to obesity are available at http://www.soph.uab.edu/statgenetics/Research/Tables/YLL-Calculation-Steps.pdf.
We derived population-based data on BMI distribution from the Third
National Health and Nutrition Examination Survey (NHANES III). NHANES III
collects information about health and diet in a representative sample of the
civilian, noninstitutionalized US population. This survey also estimates the
prevalence of a variety of health conditions and risk factors, such as obesity.
NHANES combines a home interview with health tests, which are performed in
a mobile examination center. NHANES III has been described in detail elsewhere.9,10 In brief, NHANES III represents a
6-year study, involving two 3-year phases, conducted from 1988 to 1994. The
data used to derive estimates of the population-based BMI distribution are
from both phases of the NHANES III data collection. Mexican Americans, non-Hispanic
blacks, and older adults were oversampled in NHANES III to ensure weighted,
unbiased estimates from these particular groups. Herein, only black and white
subjects were used because sample sizes of other groups were generally insufficient
to allow reasonably precise estimates.
Body mass index was divided into ordered, nonoverlapping categories
starting with less than 17 (ie, 17 to <18; 18 to <19; 20 to <21;
21 to 45; or ≥45). Second, for each race and sex group, the proportion
of individuals within each BMI category was estimated. The proportions were
calculated using a smoothing procedure based on moving averages. This procedure
was necessary because continuous scales made categorical with fine gradations
may result in insufficient data to produce precise estimates. Smoothing is
a nonparametric way to minimize this problem. Specifically, we first estimated
the probability of being in each of a series of 34 overlapping BMI intervals
starting with the interval BMI of less than 17, then progressing through BMI
intervals with widths of 5 (≤13 to <18; ≤14 to <19; ≤44 to
<49; and the open interval of ≥45). For each interval, we assigned subjects
a score of 1 if their observed BMI was within the interval and zero if it
was not. This resulted in 34 binary variables. Each of these binary variables
was then regressed on age to a third-degree polynomial via logistic regression.
We chose a model with a cubic polynomial because past research, which
included the NHANES I data, showed that (over the adult life span) the change
in BMI with age is convex and can be well characterized by a third-degree
polynomial or less.11 Using the resulting logistic
regression equations, the probability of being in each of these broad intervals
was calculated for each age from 18 to 85 years. Then, within each age, the
probability of being in each integer-defined BMI category was calculated as
the moving average of all the broader BMI bins containing the integer-defined
BMI category of interest. These smoothed proportions were used to represent
the probability of being in a given BMI category at each age.
Third, also using NHANES III data, we estimated the mean BMI within
each BMI category for each race and sex group. This was simply estimated as
the observed arithmetic mean within each sex by race by BMI category grouping.
To estimate the HR for death at a given BMI level in each year of adult
life, we combined data from the First National Health and Nutrition Epidemiologic
Follow-up Study (NHEFS) and the NHANES II Mortality Study (NH2MS).12
The NHEFS is a national longitudinal study that was designed to investigate
the relationships between clinical, nutritional, and behavioral factors assessed
in NHANES I and II and subsequent morbidity, mortality, and hospital use,
as well as changes in risk factors, functional limitation, and institutionalization.12 The NHEFS includes all persons aged 25 to 74 years
who completed a medical examination during NHANES I from 1971 to 1975 (n =
14 407). Follow-up vital statistics were collected through 1992. Of all
the participants, 96% have been successfully traced at some point through
follow-up in 1992.12
The NH2MS cohort is composed of adults who were aged 30 to 75 years
at the time of their NHANES II examination between 1976 and 1980 (n = 9252).
Two participants were unable to be followed-up because of incomplete personal
identifying data and are considered lost to follow-up. The NH2MS cohort members
were tracked through 1992 by searching national databases containing mortality
and cause-of-death information. The 2 datasets were combined to increase sample
size and precision of estimates.
Using these data, Cox regression models were used with mortality as
the outcome and BMI, BMI2, age, age2, and their interaction
terms as covariates. Potential age, race, and sex interactions were accounted
for by fitting separate models to each race and sex group. Interactions of
BMI and BMI2 with age2 were not used because prior research
indicated that change in the BMI parameters appears to be roughly linear in
age.13 In addition, removal of such terms greatly
reduced collinearity. Despite this, there may be some collinearity, particularly
among variables such as age and age2. However, this is not a major
concern in this situation because collinearity will increase the variance
of the coefficients, but will not bias the parameter estimates or the overall
predictions. Prior to estimating the Cox regression model, BMI was transformed
to BMI inverse (1/BMI). We chose inverted BMI as a predictor instead of BMI
because prior research has shown that inverted BMI is more suitable for modeling
the convex but asymmetrical relationship between BMI and mortality.14,15 Within every sex and age group examined
in NHANES III, inverted BMI was more highly correlated with body fat than
was BMI.16 Smoking status (defined as current,
former, never, or unknown) was controlled for in all analyses. Using the resulting
equation, we calculated the estimated HR for each BMI category at each age
interval by substituting the mean BMI in each BMI category for the BMI in
the equation and the midpoint of the age interval (eg, 18.5 for 18- to 19-year-olds)
for age in the equation. As a sensitivity analysis, we also calculated the
estimated HRs across the categories of BMI using the sample weights that account
for the complex sampling design of NHEFS and NH2MS. These weighted estimates
were extremely similar to the unweighted estimates and when they differed,
the HRs for obesity were higher with than without weighting, suggesting that
our results may be conservative.
To test the proportionality assumption, Schoenfeld residuals were computed
for each variable in the model. When the proportionality assumption is met,
Schoenfeld residuals should be independent of survival time. Therefore, we
plotted these residuals against survival time for each independent variable
involving BMI (ie, BMI; BMI2; BMI × age; BMI2 ×
age) and also computed that Spearman nonparametric correlation between these
residuals and survival time. This was performed separately for each of the
4 sex and race groups. In each group, all 4 plots gave no indication of a
nonrandom pattern of association. Moreover, across all 4 variables in all
4 groups, the largest Spearman r2 for
the correlation with survival time was less than 0.5% of the variance. Thus,
there is substantial evidence for the validity of the proportionality assumption.
All logistic regression models were fit using SPSS statistical software (Version
10.0.7; SPSS Inc, Chicago, Ill).
The life table for the total population of the United States in 1999
was used to derive information on the probability of death during each year
of life (http://www.cdc.gov/nchs/data/nvsr/nvsr50/nvsr50_06.pdf).
For each race- and sex-specific age interval, we obtained an estimate of the
total probability of death within the interval, which was conditional on having
lived to the start of that interval.
Using data from the (1) US Life Tables (1999); (2) Third National Health
and Nutrition Examination Survey (NHANES III; 1988-1994); and (3) First National
Health and Nutrition Epidemiologic Follow-up Study (NHANES I and II; 1971-1992)
and NHANES II Mortality Study (1976-1992), we were able, for each age interval,
in each of 4 race and sex groups, to obtain an estimate of the probability
of death within the interval, which was conditional on having lived to the
start of that interval and being in the first BMI category. The probability
of death within the interval conditional on having lived to the start of that
interval and being in a given BMI category was also estimated. For a person
of a given age in a given BMI category, we estimated their expected age of
death (operationally defined as the median age of death for a person with
their starting age and BMI). Finally, the YLL for a person of a given age
in a given BMI category is the difference relative to being in the reference
category (ie, BMI = 24). A BMI of 24 was chosen as the reference category
because it represents the upper bound of desirable weight.
The YLL due to obesity estimates for each sex and race group (compared
with a BMI of 24) for ages 20, 30, 40, 50, 60, and 70 years are displayed
in Figure 1 and Figure 2. A complete tabulation of the YLL estimates across the
entire range of BMI is posted on our Web site (http://www.soph.uab.edu/statgenetics/Research/Tables/YLL.htm). Among whites, the overall pattern suggests a J- or U-shaped association.
For example, YLL would be 1 to 9 in individuals with low BMIs (<17 to 19)
and 9 to 13 in individuals with high BMIs (≥35). White men aged 20 years
with BMIs greater than 45 are estimated to have 13 YLL relative to white men
aged 20 years with BMIs of 24. A similar, although less pronounced pattern
occurs throughout the upper range of BMI (Figure 1). Among white women, the pattern shows less variability
across the range of BMI distribution as a function of age. White women aged
20 to 30 years with BMIs greater than 45 are estimated to have 8 YLL due to
obesity (Figure 1).
The overall pattern of findings among blacks was somewhat different.
Among black men, estimated YLL due to obesity did not begin for any age group
until a BMI of 32 was reached. Obesity appeared to be associated with a slightly
increased life expectancy across much of the moderate obesity range for the
older age groups (60-70 years). Twenty was the maximum YLL found among black
men aged 20 years with BMIs greater than 45 (Figure 2). The maximum YLL for black women aged 20 years with BMIs
greater than 45 was 5 (Figure 2).
Using 1999 US Life Tables and population-based data to derive estimates
of the BMI distribution for each year of adult life, as well as the HR for
death for each BMI category in each year of adult life, we found that obesity
has a profound effect on life span. That is, mirroring the association between
BMI and mortality, a J- or U-shaped association between BMI and YLL at all
ages was observed. Moreover, the optimal BMI (ie, the BMI associated with
the greatest longevity) for adults aged 18 to 85 years is approximately 23
to 25 for whites and approximately 23 to 30 for blacks.
A 20-year-old white male with a BMI greater than 45 is estimated to
have 13 YLL due to obesity. Assuming a life expectancy of 78 years, this translates
into a 17% reduction in total life expectancy. When one considers that a 20-year-old
white male is expected to live another 58 years, a 13-year reduction due to
obesity actually represents a 22% reduction in remaining years of life. White
women aged 20 years with BMIs greater than 45 are estimated to have 8 YLL
due to obesity, which is a 10% reduction in total life expectancy. Assuming
61 years of life remaining for a 20-year-old woman, an 8-year reduction due
to obesity actually represents a 13% reduction in remaining years of life.
Thus, our findings suggest that obesity has a marked effect on the life span
of whites, and that the risk of increased YLL was greatest at younger ages.
The pattern of findings among blacks was somewhat different. Obesity
was associated with only slightly increased life expectancy across much of
the overweight and moderate obesity range for most age groups. A consistent
reduction in expected life expectancy was not observed until BMIs of 37 to
38 for women and 32 to 33 for men were reached. The maximum YLL was 20 among
black men aged 20 years with BMIs greater than 45. This is a 29% reduction
based on a life expectancy of 70 years and a 40% reduction in remaining years
of life. Given the small sample size of black men with extremely high BMIs,
it is worth considering the more conservative estimate obtained among black
men with BMIs of 44 to 45. For these 20-year-olds, the YLL was 11, which is
a 16% reduction in total life expectancy and a 22% reduction in remaining
years of life. Among black women aged 20 years with BMIs greater than 45,
the YLL was 5, which is a 6.6% reduction in total life expectancy of 76 years
and an 8.9% reduction in remaining years of life. Despite the different pattern
of findings from whites, we also observed that YLL were greatest at younger
In one respect, our findings run counter to those reported by Stevens
et al8 in that the YLL attributable to obesity
increased with age, but declined for those in the oldest decade (70-79 years).
A possible explanation for the divergent findings is that we estimated YLL
across the remaining years of life while Stevens et al restricted the analyses
to a 12-year period using data from the Cancer Prevention Study I. This approach
may have led to both an underestimation of YLL and a spurious positive association
between baseline age and YLL. This is because the method of estimating YLL
used by Stevens et al defined the observed YLL to be zero for all subjects
who did not die within the duration of the study. This results in an overall
underestimation of YLL because those individuals who will die before the median
life span for their demographic group (ie, would have an YLL >0), but did
not die during the study, are coded as YLL = 0. Moreover, younger individuals
(independent of BMI) are less likely to die than older people within any defined
period. This presumption results in a greater underestimation for younger
rather than older individuals and potentially leads to a spurious positive
correlation between YLL and age. Our YLL estimates also seem markedly higher
than those obtained by Stevens et al who considered all levels of obesity
as a single class (ie, BMI ≥30) so the results are not easily compared
directly with ours. Nevertheless, the YLL associated with obesity did not
exceed 1 for any age or sex group considered.
There was some difference in the pattern of findings in YLL due to obesity
between whites and blacks. This is actually consistent with what has been
observed regarding the association between BMI and mortality between these
races.17 For example, in a cohort of 2731 black
women who were members of the Kaiser Foundation Health Plan and were followed-up
for 15 years, Wienpahl et al18 found an essentially
flat association between BMI and mortality across the entire range of BMI.
Other investigators19- 22 have
obtained similar results, which suggests that the effect of a given BMI increase
on mortality rate may be different and sometimes less deleterious among blacks
relative to whites.
A recent review17 of the literature on
the association between BMI and mortality in blacks indicates that obesity
resulted in a smaller increase in mortality among blacks compared with whites.
Using data from the Cancer Prevention Study II, a J- or U-shaped pattern between
BMI and relative rates of mortality among whites was obtained. In contrast,
the pattern among black men and women suggests that the only category in which
the relative mortality rate is consistently and substantially elevated is
among black women with BMIs of less than 18.5.
At least 4 possible explanations may account for the differential relationship
between moderately high levels of BMI, mortality, and YLL across races. First,
the true causal effect of BMI on mortality rate may differ between blacks
and whites. Second, blacks and whites may be exposed to different competing
risks for mortality and this may affect the outcome.23 That
is, distributions of age, health status, socioeconomic status, and other variables
that can affect mortality rate may differ by race and this can affect the
estimated HR which, in turn, influences the YLL estimates. For example, homicide
is the leading cause of death among blacks aged 15 to 34 years, and the third
leading cause of potential YLL.24 Thus, it
is possible that homicides, a cause of death presumably independent of BMI,
may disproportionately account for excess deaths among blacks, particularly
males, thereby altering the influence of obesity on YLL estimates. Third,
there may be different distributions of confounding variables among blacks
compared with whites. Fourth, the critical variable may be body composition,
not BMI, and the relationship between metabolism, BMI, and body composition
(central adiposity) may differ by race, especially among women.25,26 These
4 potential explanations are neither mutually exclusive nor exhaustive.
We also observed some sex differences in the association between obesity
and YLL. On the whole, independent of race, men were at increased YLL risk.
Among white men, the increased YLL risk was generally more uniform across
age than it was for white women. This is consistent with Stevens et al,8 who also found that YLL was higher among men than
women with comparable BMIs.
The results of this study should be interpreted in light of several
limitations. Although elevated BMI is the primary index of obesity used in
most studies, it is a proxy of adiposity and may not provide the best estimate
of the association between obesity and outcomes such as mortality or YLL.
Body mass index involves fat mass and fat-free mass, so its use may mask any
differential health consequences associated with fat mass and fat-free mass,27- 30 which
suggests that future studies should obtain not only BMI, but direct measures
of body composition as well.
Due to insufficient sample size, the association between obesity and
YLL could not be reliably estimated for other racial/ethnic groups, including
Mexican-Americans and Pacific-Islander Americans, groups that are known to
have high prevalences of overweight and obesity. Until databases of sufficient
size are available for these racial groups, the association between BMI and
YLL will remain unknown.
A related issue concerns the relatively small sample size of individuals
in the upper BMI categories. We chose to collapse the upper BMI categories
at 45 or greater, as opposed to some other cut point because of the increasing
proportion of individuals with BMIs above 40 and the markedly accelerated
increase in mortality rate for individuals with high BMI levels.31,32 To
address whether the relative sparseness of data in the upper BMI categories
may have rendered YLL estimates imprecise, we reversed the order of the pi's
for the upper BMI categories for white men and black women to evaluate the
extent to which this influenced YLL estimates. Less than 1% of the YLL estimates
for white men in the upper BMI categories were altered, and in all of these
cases, the changes were minimal (ie, ± 1 year). For black women, there
were more changes (approximately 8%), but the magnitude of these changes on
YLL estimates were small (±1 year). Thus, although sample sizes in
the upper BMI categories were modest, our results appear to be quite robust
to any misestimation of the frequency distribution of BMI at the upper end
of the BMI continuum.
Although an estimate of YLL due to obesity is interesting and important,
it is only 1 consequence of obesity. A recent review33 indicates
that obesity significantly impairs quality of life, arguably a more potent
marker of the effect of obesity because quality-of-life deficits are experienced
in the moment rather than anticipated sometime in the future.
We controlled for smoking status as a potential confounder of the association
between BMI and YLL. Specifically, we categorized individuals as current,
former, or never smokers, and unknown. The number of cigarettes smoked was
not taken into account because of the limitation of the data. We also did
not consider that changes in smoking prevalence are occurring over time. Given
that smoking affects both body weight and mortality rate, this may affect
the YLL associated with obesity at future time points. Thus, future researchers
may wish to reestimate YLL values at periodic intervals to see if changes
We also did not control for the possible confounding effects of subclinical
or occult disease. This is because it is unclear exactly how to control for
something that is, by definition, unobservable. Excluding individuals who
died early in follow-up (eg, ≤5 years) to reduce confounding due to preexisting
disease has been shown to be ineffective and possibly even exacerbating.28,29,34 Nonetheless, within
the context of BMI and YLL studies, it is possible that preexisting occult
disease could confound the association between BMI and YLL and lead spuriously
to a diminution in the observed increase in YLL across the upper range of
BMI. To the extent that confounding due to occult disease exists, our YLL
estimates are likely to be underestimates.
Our YLL calculations assume that an individual's BMI remains constant
across age. We sought to address the question: Given that an individual has
a BMI of 37, for example, how much longer would he/she be expected to live
if the BMI was 24? This is different than addressing the question: Given that
an individual has a BMI of 37, for example, and gains or loses weight at the
same rate as others with BMIs of 37, for example, how much longer would he/she
be expected to live if the BMI was 24 and gained or lost weight at the same
rate as others with BMIs of 24? The former question is more germane to public
health and clinical communication.
Given that we used information from 3 separate and different data sets
in our calculation procedure, we were unable to provide confidence intervals
for our YLL estimates. We are unaware of any developed analytic formula that
would allow easy calculation of SEs and confidence intervals. Computer-intensive
sampling procedures could be used, but that is a topic for future research.
It is likely that our YLL estimates will be least precise when there is less
data such as among blacks and among extremely obese individuals.
Finally, we did not determine statistical power a priori. Although,
given our sample size, this is not a limitation per se for most of our analyses,
it should be noted that as one moves to the extremes of the distribution of
predictor variables under study, fewer data are available and estimates become
less stable, and the HRs can substantially influence estimates of YLL. Therefore,
it will be useful for future research to replicate and refine the results
herein using larger data sets, particularly among nonwhites.
There are also several strengths of the study. We used large nationally
representative samples to derive our estimates of BMI distribution and HR
of death across the life span. We also used an analytic approach that generated
YLL estimates for each remaining year of life along the range of BMI. Moreover,
our YLL estimates are likely conservative because we did not exclude cohort
members (eg, ever smokers, weight fluctuators).
Our results confirm that obesity is a major public health problem that
appears to lessen life expectancy markedly, especially among individuals in
younger age groups. Among blacks, the pattern of findings suggests that overweight
and obesity may not decrease life expectancy until a BMI of approximately
32 to 33 for men and 37 to 38 for women is reached. At these BMI levels, longevity
begins to decrease, especially among individuals in the younger age categories.
Our estimates of YLL due to obesity strongly support the public health recommendation
for adults to avoid obesity.