Hoffmann and colleaguesArticle assessed the accuracy
of noninvasive coronary angiography (CA) using multislice computed tomography
(MSCT) compared with standard invasive CA to detect obstructive coronary artery
disease in 103 consecutive patients who had both tests. The authors found
that MSCT had reasonably high accuracy for detecting significant obstructive
coronary artery disease compared with invasive CA. In an editorial, GarciaArticle discusses the promise and limitations of MSCT.
Women who engage in physical activity after a breast cancer diagnosis
have improved quality of life, but whether regular physical activity confers
a survival advantage is not known. Holmes and colleagues assessed breast cancer
mortality in relation to reported physical activity a median of 38 months
after diagnosis among participants in the Nurses’ Health Study. The
authors found that physical activity was associated with improved survival,
with greatest benefit observed in women whose activity was equivalent to walking
3 to 5 h/wk at an average pace.
Among adults 18 to 54 years of age, the prevalence of suicide has declined
about 6% since the early 1990s, but whether suicide-related behaviors such
as thoughts, plans, gestures, and attempts have also declined is not clear.
To address these questions, Kessler and colleagues analyzed self-reported
data on suicide-related behaviors and treatment from 2 nationally representative
surveys conducted in 1990-1992 and 2001-2003. Comparing data from the 2 surveys,
the authors found little change in the number of persons reporting suicide-related
behaviors, despite a substantial increase in treatment for persons who made
a suicide gesture or attempt.
Elevated titers to Epstein-Barr virus (EBV) have been reported in persons
with multiple sclerosis (MS), but the temporal relationship of EBV infection
to onset of MS is not known. In this issue of JAMA,
Levin and colleaguesArticle report data on EBV antibody
titers and disease onset derived from 69 case-control sets. Baseline antibody
titers to several EBV antigens were significantly higher in cases than controls,
and the mean onset of MS symptoms was 4.0 years after baseline blood collection.
In an editorial, Fontanarosa and DeAngelisArticle explain
the circumstances that led to a reanalysis and new report of these data.
Prior studies suggest that international adoptees have more behavioral
and mental health problems than children adopted within their home country
or nonadoptees. In a meta-analysis of studies addressing adoptee mental health
and behavioral problems, Juffer and van IJzendoornArticle found
that adoptees in general had more behavioral problems and received more mental
health services than nonadoptees. However, international adoptees had fewer
behavioral problems and were less often referred to mental health services
than local adoptees. In an editorial, MillerArticle discusses
the study findings and directions for future research.
As the US population ages, the cost of osteoporosis and its related
fractures is expected to grow. But an increasing body of research is providing
better tools for managing this condition.
Meta-analysis of data from 79 cohort and case-control studies failed
to find strong evidence of a marked increase in cancer risk from personal
use of hair dyes.
A proposed schema for psychiatric diagnoses focused on cause rather
Persons with bipolar disorder are at increased risk of certain medical
For your patients: Information about suicide.
This Week in JAMA . JAMA. 2005;293(20):2441. doi:10.1001/jama.293.20.2441