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This Week in JAMA
April 5, 2006

This Week in JAMA

JAMA. 2006;295(13):1481. doi:10.1001/jama.295.13.1481

The Organization for the Assessment of Strategies for Ischemic Syndromes (OASIS-6) clinical trial investigatorsArticle assessed the effects of adding fondaparinux, a factor Xa inhibitor, to usual care, which included unfractionated heparin when clinically indicated vs placebo, on patient morbidity and mortality following acute ST-segment elevation myocardial infarction (STEMI). The OASIS-6 investigators report that patients receiving fondaparinux had significantly reduced death or reinfarction at 30 days vs usual care. In an editorial, CaliffArticle discusses the implications of the trial results for care of patients following STEMI.


In the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 2 (ISAR-REACT 2) Trial Article, patients with non–ST-segment elevation acute coronary syndromes having percutaneous coronary intervention after pretreatment with 600 mg of clopidogrel received abciximab or placebo to assess whether abciximab is associated with clinical benefit. The ISAR-REACT 2 Trial investigators report that compared with placebo, patients with elevated troponin levels who received abciximab had a reduced risk of a composite outcome of death, myocardial infarction, or urgent target vessel revascularization within 30 days of randomization. In an editorial, Steinhubl and CharnigoArticle discuss the importance of troponin levels for determining optimal therapy for patients with an acute coronary syndrome.

Calorie Restriction, Metabolism, and Longevity

Heilbronn and colleaguesArticle examined the effects of 6 months of calorie restriction on biomarkers of calorie restriction, energy expenditure, and oxidative stress in healthy overweight adults. They found that those who restricted their caloric intake had reduced fasting insulin levels and core body temperature, reduced metabolic rate beyond the level expected from reduced body mass, and reduced DNA damage compared with a weight maintenance diet. In an editorial, FontanaArticle discusses the effects of calorie restriction on markers of aging.

Overweight and Obesity in the United States

Ogden and colleagues used data from the 1999-2000, 2001-2002, and 2003-2004 National Health and Nutrition Examination Surveys to assess the prevalence of and trends in overweight in children and adolescents and obesity in adults. In this 6-year period, the prevalence of overweight among children and adolescents and obesity among men increased significantly. Among women, obesity prevalence did not change, but the prevalence of severe obesity in women was nearly twice that in men.


Intensive statin therapy can slow or halt progression of atherosclerosis, but whether it causes atheromas to regress is not known. In the ASTEROID (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) trial, patients who required coronary angiography and had at least 1 coronary artery obstruction with more than 20% luminal narrowing received 40 mg/d of rosuvastatin for 2 years. Nissen and colleaguesArticle report that the therapy was associated with intravascular ultrasound-documented regression of atherosclerosis. In an editorial, Blumenthal and KapurArticle discuss design limitations of ASTEROID and the need to assess whether atheroma regression is associated with a reduction in clinical events.

A Piece of My Mind

“The people in this area do not have many options for medical care. Their community is rife with hunger, poverty, malnutrition, and high infant mortality.” From “Duffle Bag Medicine.”

Medical News & Perspectives

The performance of the nation’s first fully equipped mobile surgical hospital, deployed to aid survivors of Hurricane Katrina, raises new questions about hospital surge capacity in the event of future disasters.


Clinical examination and computer models of upper gastrointestinal disease are inadequate to distinguish functional from organic causes of dyspeptic symptoms.

Author in the Room Teleconference

Join William C. Taylor, MD, on Wednesday, April 19, 2006, from 2 to 3 PM eastern time to discuss approaches to screening for colonoscopy. To register, go to

Audio Commentary

Dr DeAngelis summarizes and comments on this week's issue. Go to

JAMA Patient Page

For your patients: Information about dyspepsia.