[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.179.146. Please contact the publisher to request reinstatement.
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Views 8,761
Citations 0
Comment & Response
December 22/29, 2015

Notice of Retraction: Ahimastos AA, et al. Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial. JAMA. 2007;298(13):1539-1547.

Author Affiliations
  • 1Baker IDI Heart and Diabetes Institute, Melbourne, Australia
  • 2Royal Melbourne Hospital, Melbourne, Australia
  • 3Monash Heart, Clayton, Australia
  • 4Murdoch Childrens Research Institute and University of Melbourne, Melbourne, Australia
JAMA. 2015;314(24):2692-2693. doi:10.1001/jama.2015.16678

To the Editor We wish to retract the article “Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial,” published in the October 3, 2007, issue of JAMA,1 based on inadequate validation of primary data sources and data misrepresentation. An independent review was conducted by the Baker IDI Heart and Diabetes Institute following an admission of scientific misconduct by the first author (Anna A. Ahimastos, PhD) in relation to the data included in another study2 that has since been retracted.3 This review resulted in our decision to retract this additional article.1 We do not believe that management guidelines for Marfan syndrome have been changed as a result of this small clinical trial.

While clinical governance procedures have been strengthened since publication of this study, the Institute has commenced a review with the purpose to further strengthen current audit practices and to minimize any possible risk of recurrence of such behavior. We were not found to be involved in any research misconduct, but we do acknowledge the responsibility for our authorship of this article and for supervising the overall study and sincerely apologize to the editors, reviewers, and readers of JAMA. We are committed to correcting the public record, notifying relevant stakeholders, and implementing practices to prevent recurrence.

Back to top
Article Information
Section Editor: Jody W. Zylke, MD, Deputy Editor.

Corresponding Author: Bronwyn A. Kingwell, PhD, Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne VIC 3004, Australia (bronwyn.kingwell@bakeridi.edu.au).

Published Online: November 23, 2015. doi:10.1001/jama.2015.16678.

References
1.
Ahimastos  AA, Aggarwal  A, D’Orsa  KM,  et al.  Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. JAMA. 2007;298(13):1539-1547.
PubMedArticle
2.
Ahimastos  AA, Walker  PJ, Askew  C,  et al.  Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460.
PubMedArticle
3.
Ahimastos  AA, Askew  C, Leicht  A,  et al.  Notice of retraction: Ahimastos AA, et al. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460. JAMA. 2015;314(14):1520-1521.
PubMedArticle
×