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April 18, 2017

Errors in Study Group Numbers and Outcome Interpretation

JAMA. 2017;317(15):1584. doi:10.1001/jama.2017.2972

The Editorial entitled “Rational Use of Antibiotics in the ICU: Balancing Stewardship and Clinical Outcomes”1 published in the October 8, 2014, issue of JAMA, included errors in the numbers of participants randomized and inaccurate sentences regarding the findings of the accompanying trial.2 The corrections in the Editorial are to accommodate the retraction and replacement of the trial. The numbers of participants, reported in the third paragraph of the Editorial, should be 6040 patients randomized to selective digestive tract decontamination (SDD) and 5957 randomized to selective oropharyngeal decontamination (SOD). The last sentence of the third paragraph is revised from reflecting no differences in any outcomes by group to the following: “Compared with SOD, SDD was associated with lower mortality and length of stay.” Finally, the penultimate sentence in Editorial about favoring SOD as a more reasonable approach has been removed. This article was corrected online.

Kollef  MH, Micek  ST.  Rational use of antibiotics in the ICU: balancing stewardship and clinical outcomes.  JAMA. 2014;312(14):1403-1404.PubMedArticle
Oostdijk  EAN, Kesecioglu  J, Schultz  MJ,  et al.  Effects of decontamination of the oropharynx and intestinal tract on antibiotic resistance in ICUs: a randomized clinical trial.  JAMA. 2014;312(14):1429-1437.PubMedArticle