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December 20, 1971

Cardiac Effects of a Cocktail

Author Affiliations

From the Department of Medicine, Misericordia-Fordham Hospital Affiliation, Bronx, NY.

JAMA. 1971;218(12):1799-1802. doi:10.1001/jama.1971.03190250025006

The hemodynamic effects of a cocktail in cardiac disease have not been previously studied, to our knowledge. Ten patients with cardiac disease and four normals underwent cardiac catheterization. Hemodynamic measurements were obtained prior to and 30 minutes after oral ingestion of 2 oz of Canadian whiskey. With alcohol, all of the patients with cardiac disease demonstrated a fall in the cardiac index and stroke index. Alcohol produced in the normals an increase in these measurements. The cardiac rate, systemic blood pressure, and pulmonary artery pressure were essentially unchanged in both groups. Small amounts of alcohol can impair cardiac function in patients with cardiac disease.

Riff DP, Jain AC, Doyle JT:  Acute hemodynamic effects of ethanol on normal human volunteers . Amer Heart J 78:592-597, 1969.Article
Juchems R:  Hemodynamic effects of ethyl alcohol in man . Amer Heart J 78:133-135, 1969.Article
Conway N:  Hemodynamic effects of ethyl alcohol in patients with coronary heart disease . Brit Heart J 30:638-644, 1968.Article
Blomqvist G, Saltin B, Mitchell JH:  Acute effects of ethanol ingestion of the response to submaximal and maximal exercise in man . Circulation 42:463-470, 1970.Article
Wendt VE, Ajluni R, Bruce TA, et al:  Acute effects of alcohol on the human myocardium . Amer J Cardiol 17:804-812, 1966.Article
Regan TJ, Levinson GE, Oldewurtel HA, et al:  Ventricular function in non-cardiacs with alcoholic fatty liver: Role of ethanol in the production of cardiomyopathy . J Clin Invest 48:397-407, 1969.Article
Gillespie JA:  Vasodilator properties of alcohol . Brit Med J 2:274-277, 1967.Article
Wendt VE, Wu C, Balcon R, et al:  Hemodynamic and metabolic effects of chronic alcoholism in man . Amer J Cardiol 15:175-184, 1965.Article
Gimeno AL, Gimeno MF, Webb JL:  Effect of ethanol on cellular membrane potential and contractility of isolated rat atrium . Amer J Physiol 203:194-200, 1962.
Regan TJ, Karoxenidis G, Moschos CB, et al:  The acute metabolic hemodynamic responses of the left ventricle to ethanol . J Clin Invest 45:270-280, 1966.Article
Mendoza LC, Hellberg K, Rickart A, et al:  The effect of intravenous ethyl alcohol on the coronary circulation and myocardial contractility of the human and canine heart . J Clin Pharma col 11:165-176, 1971.
Spann JF Jr, Mason DT, Beiser GD, et al:  Actions of ethanol on the contractile state of the normal and failing cat papillary muscle, abstracted . Clin Res 16:249, 1968.