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November 2016 - July 1883

Decade

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Issue

April 4, 2012, Vol 307, No. 13, Pages 1337-1447

This Week in JAMA

This Week in JAMA

Abstract Full Text
JAMA. 2012;307(13):1337-1337. doi:10.1001/jama.2012.405
Viewpoint

Incentives in HealthDifferent Prescriptions for Physicians and Patients

Abstract Full Text
JAMA. 2012;307(13):1375-1376. doi:10.1001/jama.2012.387

Patient Satisfaction, Prescription Drug Abuse, and Potential Unintended Consequences

Abstract Full Text
JAMA. 2012;307(13):1377-1378. doi:10.1001/jama.2012.419

The Challenge of Individualizing Treatments for Patients With Breast Cancer

Abstract Full Text
JAMA. 2012;307(13):1379-1380. doi:10.1001/jama.2012.409
A Piece of My Mind

Filling the Void

Abstract Full Text
JAMA. 2012;307(13):1381-1382. doi:10.1001/jama.2012.403
Original Contribution

Effect of Oxaliplatin, Fluorouracil, and Leucovorin With or Without Cetuximab on Survival Among Patients With Resected Stage III Colon CancerA Randomized Trial

Abstract Full Text
free access
JAMA. 2012;307(13):1383-1393. doi:10.1001/jama.2012.385

A combination of leucovorin, fluorouracil, and oxaliplatin (FOLFOX) is standard therapy following resection of stage III colon cancer. In a multicenter randomized trial that involved 2686 patients with resected stage III colon cancer, Alberts and colleagues assessed the potential benefit of adding cetuximab—an epidermal growth factor receptor antibody with known efficacy against metastatic colon cancer—to a modified FOLFOX regimen (mFOLFOX6). The authors found no benefit on disease-free survival from the addition of cetuximab compared with mFOLFOX6 alone. In an editorial, Segal and Saltz discuss the fallacy of assuming that drugs effective against metastatic disease will be effective in the adjuvant setting.

Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk

Abstract Full Text
free access has multimedia
JAMA. 2012;307(13):1394-1404. doi:10.1001/jama.2012.388

In a multicenter, 3-year study involving 2662 women with an elevated (intermediate) risk of breast cancer and dense breast tissue on prior mammographic examinations, Berg and colleagues found that the addition of annual screening ultrasound or a single screening MRI to annual mammography resulted not only in increased detection of incident breast cancers but also in increased false-positive findings.

Association of Diagnostic Coding With Trends in Hospitalizations and Mortality of Patients With Pneumonia, 2003-2009

Abstract Full Text
free access
JAMA. 2012;307(13):1405-1413. doi:10.1001/jama.2012.384

To examine whether recent declines in mortality among patients hospitalized with pneumonia could be related to temporal changes in diagnostic coding, Lindenauer and colleagues analyzed data from the 2003-2009 Nationwide Inpatient Sample (representing 5 million to 8 million discharges annually) for patients with either a principal diagnosis of pneumonia or pneumonia secondary to sepsis or respiratory failure. Among the authors' findings were that hospitalization and mortality rates for patients with a principal diagnosis of pneumonia decreased, whereas hospitalizations for patients with a secondary diagnosis of pneumonia increased from 2003 to 2009. In an 404, Sarrazin and Rosenthal discuss limitations of administrative data to evaluate trends in health care outcomes.

Oral Fluoroquinolones and the Risk of Retinal Detachment

Abstract Full Text
free access
JAMA. 2012;307(13):1414-1419. doi:10.1001/jama.2012.383

Fluoroquinolones are associated with a number of adverse effects including ocular toxicity and tendon rupture. In an analysis of physician visit and prescription drug data (2000-2007) from a cohort of 989 591 ophthalmology patients in British Columbia, Etminan and colleagues examined the association between oral fluoroquinolone use and the risk of retinal detachment. The authors identified 4384 patients with retinal detachment and 43 840 control patients and found that compared with nonuse, current use of oral fluoroquinolones was associated with an increased risk of retinal detachment, although the absolute risk (4 per 10 000 person-years) was small.

Editorial

Antitumor Activity in Metastatic Disease Does Not Predict Efficacy in the Adjuvant Setting

Abstract Full Text
JAMA. 2012;307(13):1431-1432. doi:10.1001/jama.2012.410

Finding Pure and Simple Truths With Administrative Data

Abstract Full Text
JAMA. 2012;307(13):1433-1435. doi:10.1001/jama.2012.404
Clinical Crossroads

Management of Ovarian CancerA 75-Year-Old Woman Who Has Completed Treatment

Abstract Full Text
has expired quiz
JAMA. 2012;307(13):1420-1429. doi:10.1001/jama.2012.269

Ms W, a 75-year-old woman, is in complete remission after surgery and postoperative chemotherapy for stage IIIC epithelial ovarian cancer. In this Clinical Crossroads article, Konstantinopoulos and Awtrey discuss the signs, symptoms, and risk factors for ovarian cancer; prognostic factors and surgical and postoperative medical management; and current recommendations for ovarian cancer screening and patient follow-up.

Clinical Crossroads Update

Update: A 41-Year-Old Woman With Menorrhagia, Anemia, and FibroidsReview of Treatment of Uterine Fibroids

Abstract Full Text
JAMA. 2012;307(13):1430-1430. doi:10.1001/jama.2012.411
Medical News & Perspectives

Immunization Recommendations Expanded for Hepatitis B, HPV, Pertussis Vaccines

Abstract Full Text
JAMA. 2012;307(13):1353-1354. doi:10.1001/jama.2012.367

Medical Reserves Answer Call to Service

Abstract Full Text
JAMA. 2012;307(13):1354-1355. doi:10.1001/jama.2012.369

Study: Vast Majority of C difficile Infections Occur in Medical Settings

Abstract Full Text
JAMA. 2012;307(13):1356-1356. doi:10.1001/jama.2012.380
Letters

Life Expectancy After Treatment for Systolic Hypertension

Abstract Full Text
JAMA. 2012;307(13):1368-1369. doi:10.1001/jama.2012.389

Life Expectancy After Treatment for Systolic Hypertension—Reply

Abstract Full Text
JAMA. 2012;307(13):1368-1369. doi:10.1001/jama.2012.390

Changes in Resting Heart Rate Over Time and Mortality

Abstract Full Text
JAMA. 2012;307(13):1369-1370. doi:10.1001/jama.2012.391

Changes in Resting Heart Rate Over Time and Mortality—Reply

Abstract Full Text
JAMA. 2012;307(13):1369-1370. doi:10.1001/jama.2012.392

Perceptions of Appropriateness of Care in the Intensive Care Unit

Abstract Full Text
JAMA. 2012;307(13):1370-1372. doi:10.1001/jama.2012.393

Perceptions of Appropriateness of Care in the Intensive Care Unit

Abstract Full Text
JAMA. 2012;307(13):1370-1372. doi:10.1001/jama.2012.394

Perceptions of Appropriateness of Care in the Intensive Care Unit—Reply

Abstract Full Text
JAMA. 2012;307(13):1370-1372. doi:10.1001/jama.2012.395

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening

Abstract Full Text
JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.396

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening—Reply

Abstract Full Text
JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.397

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening—Reply

Abstract Full Text
JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.398

Recommendations on Use of Prostate-Specific Antigen for Prostate Cancer Screening—Reply

Abstract Full Text
JAMA. 2012;307(13):1372-1374. doi:10.1001/jama.2012.399
Lab Reports

New Antiseizure Agents

Abstract Full Text
JAMA. 2012;307(13):1357-1357. doi:10.1001/jama.2012.370

Influenza A in Bats

Abstract Full Text
JAMA. 2012;307(13):1357-1357. doi:10.1001/jama.2012.371

Toxin’s Gut Protection

Abstract Full Text
JAMA. 2012;307(13):1357-1357. doi:10.1001/jama.2012.372

NSAIDs and Cancer Spread

Abstract Full Text
JAMA. 2012;307(13):1357-1357. doi:10.1001/jama.2012.373
The Cover

The Sun Through the Trees

Abstract Full Text
JAMA. 2012;307(13):1342-1342. doi:10.1001/jama.2012.381
Poetry and Medicine

The Salvation of Humor

Abstract Full Text
JAMA. 2012;307(13):1343-1343. doi:10.1001/jama.2012.318
JAMA Patient Page

Retinal Detachment

Abstract Full Text
JAMA. 2012;307(13):1447-1447. doi:10.1001/jama.2012.320
JAMA Masthead

About This Journal

Abstract Full Text
JAMA. 2012;307(13):1339-1340. doi:10.1001/jama.307.13.1339
JAMA 100 Years Ago

CHEESE—A NEGLECTED NUTRIENT

Abstract Full Text
JAMA. 2012;307(13):1350-1350. doi:10.1001/jama.2012.263
Book and Media Reviews

The Yale Guide to Ophthalmic Surgery

Abstract Full Text
JAMA. 2012;307(13):1436-1436. doi:10.1001/jama.2012.400

MRI of the Gastrointestinal Tract

Abstract Full Text
JAMA. 2012;307(13):1437-1437. doi:10.1001/jama.2012.401

The Art of Medicine: Over 2000 Years of Images and Imagination

Abstract Full Text
JAMA. 2012;307(13):1437-1438. doi:10.1001/jama.2012.402
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