To test out-of-hospital administration of glucose-insulin-potassium infusion by emergency medical services personnel in the setting of acute coronary syndromes, Selker and coauthors conducted a randomized controlled trial in 871 patients and measured the rate of progression to myocardial infarction as assessed by biomarkers and electrocardiographic evidence.
Patrick and colleagues determined the national incidence of neonatal abstinence syndrome (NAS) and maternal opiate use at the time of delivery and characterized national health care expenditures associated with NAS between 2000 and 2009.
In an editorial, Hayes and Brown discuss the epidemic of prescription opiate abuse and neonatal abstinence syndrome.
Matsushita and coauthors for the Chronic Kidney Disease Prognosis Consortium conducted a meta-analysis of data from 1.1 million adults to evaluate the risk implications of estimated glomerular filtration rate using 2 different equations. In an accompanying editorial, Kalantar-Zadeh and Amin discuss the use of estimated glomerular filtration rate in diagnosing chronic kidney disease.
To compare utilization patterns of warfarin and risk of subsequent stroke between older men and women with atrial fibrillation, Avgil Tsadok and coauthors assessed administrative data from a population-based cohort of 39 398 men and 44 115 women.
To evaluate the evidence for probiotic use in the prevention and treatment of antibiotic-associated diarrhea, Hempel and coauthors screened 12 electronic databases from database inception to February 2012 and extracted data and assessed trial quality in 82 randomized controlled trials.