To determine if hypertonic saline reduces the rate of pulmonary exacerbations in younger patients with cystic fibrosis (CF), Rosenfeld and coauthors randomly assigned 321 infants younger than 6 years with CF to receive either 7% hypertonic saline or isotonic saline. In the related 5853, Dasenbrook and Konstan discuss new clinical end points for early detection of regional lung disease.
In a randomized controlled trial of 325 primary care patients with major depressive disorder, Mohr and coauthors evaluated the completion of therapy and self-reported level of depression between patients receiving telephone-administered cognitive behavioral therapy vs those receiving face-to-face therapy.
Dr De Berardis and coauthors report on the association of aspirin use with major bleeding in patients with and without diabetes. In an
accompanying 6152, Dr Siller-Matula discusses the use of aspirin in patients.
In a prospective, international cohort study of 15 133 patients, Devereaux and colleagues analyzed the relationship between the peak fourth-generation troponin T (TnT) measurement in the first 3 days after noncardiac surgery and 30-day mortality.
Mr L, a 64-year-old man with advanced Parkinson disease, was experiencing increasing difficulty buttoning, tying his shoe laces, and periodic gait freezes. He has found some relief after an increase in his carbidopa-levodopa-entacapone regimen. Tarsy discusses treatment options including deep brain stimulation.