To test whether high-dose (vs standard-dose) multivitamin supplementation decreases the risk of human immunodeficiency virus (HIV) disease progression or death from any cause in patients with HIV initiating highly active antiretroviral therapy, Isanaka and coauthors followed up 3418 patients in Tanzania on a monthly basis for 24 months.
Carroll and coauthors used data from 3 cross-sectional National Health and Nutrition Examination Surveys to observe trends in serum lipid levels in adults between 1988 and 2010.
Moreira and coauthors investigate strategies for identifying Lynch syndrome in patients with colorectal cancer. They examine data from 4 large cohorts to consider criteria for which individuals should undergo tumor mismatch repair gene testing. In an Editorial, Ladabaum and Ford discuss screening for Lynch syndrome.
Yunos and coauthors report on the association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. In an accompanying Editorial, Waikar and Winkelmayer discuss the effects of chloride on renal function.
Although quitting smoking tobacco benefits almost all those who quit, most individual attempts to quit fail. Furthermore, two-thirds of patients try to quit without treatment or support. Rigotti explores evidence-based treatment options. In an editorial, Schroeder discusses the limitations of the evidence base for treatment of tobacco use.