To determine whether long-term multivitamin supplementation decreases the risk of major cardiovascular events among men, Sesso and coauthors randomized 14 641 male physicians participating in the Physicians’ Health Study II to receive a multivitamin or placebo. Lonn provides comment in the related Editorial.
To quantify the effect of intraoperative high-dose dexamethasone on the incidence of major adverse events, Dieleman and coauthors studied 4494 patients in the Netherlands undergoing cardiac surgery with cardiopulmonary bypass.
Safford and coauthors for the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Investigators report on the association of race and sex with risk of incident acute coronary heart disease events.
Daviglus and coauthors describe major cardiovascular disease risk factors, as well as the prevalence of coronary heart disease and stroke, among US Hispanic/Latino adults of diverse backgrounds using data from the Hispanic Community Health Study/Study of Latinos. In the Editorial, Lauer describes the value of epidemiology in shaping scientific innovation.
Gurbel and coauthors compare the effect of clopidogrel with prasugrel on platelet reactivity among 2564 patients—who were part of a substudy of the TRILOGY ASC trial—whose acute coronary syndromes, which did not include ST-segment elevation, were managed medically. In an editorial, Price discusses implications of the study for clinical practice and future research.
Wilkins and colleagues study lifetime risk estimates of total cardiovascular disease (CVD) to help project future population burden of CVD in a pooled survival analysis of 905 115 person-years of data, patient index ages 45 to 75 years, 1964-2008.