To determine the ability of citicoline to positively affect functional and cognitive status in persons with complicated mild, moderate, and severe traumatic brain injury (TBI), Zafonte and coauthors randomized 1213 patients with TBI to receive a 90-day regimen of citicoline or placebo. In the related Editorial, Ruff and Riechers discuss the importance of studies of TBI treatment.
To determine whether perioperative supplementation with omega-3 polyunsaturated fatty acids reduces postoperative atrial fibrillation, Mozaffarian and coauthors randomly assigned 1516 patients scheduled for cardiac surgery to receive perioperative fish oil or placebo.
Palen and coauthors investigated health care utilization before and after initiation of a patient online access system using a matched analysis based on 44 321 users and 44 321 nonusers of online access. In an Editorial, Bates and Wells discuss the importance of organizations knowing what to expect after the adoption of electronic health portals.
In an article summarizing the effects of nonpharmacologic treatment of behavioral symptoms in dementia in older persons, Gitlin and coauthors review evidence-based studies and describe the case of a 93-year-old man with dementia.
To compare protocolized sedation with protocolized sedation plus daily sedation interruption in critically ill patients receiving mechanical ventilation, Mehta and coauthors conducted a randomized controlled trial in 16 North American intensive care units. See related Editorial by Hall.