To determine the efficacy and safety of aldosterone antagonist therapy in clinical practice, Hernadez and coauthors measured all-cause mortality, cardiovascular readmission, and heart failure admissions by examining registry data linked to Medicare claims from 2005-2010. In an editorial Fang discusses how clinicians may interpret the study findings.
Lund and coauthors report on the association between use of renin-angiotensin system antagonists and mortality in patients with heart failure and preserved ejection fraction. In an accompanying Editorial, Fang discusses the findings of the 2 observational studies that appear in this issue.
Mérie and coauthors performed a nationwide study of thrombosis and bleeding associated with the duration of warfarin therapy after bioprosthetic aortic valve replacement surgery in 4075 patients. See the related Editorial by Mehta.
Misegades and coauthors performed a case-control study to evaluate the association between pertussis cases among California children in 2010 and receipt of 5 diphtheria, tetanus, and acellular pertussis vaccine (DTaP) doses by time since the fifth DTaP dose.
Mr R, a 57-year-old man, has a history of podagra, hyperuricemia, and mild renal insufficiency. Shmerling discusses the clinical features and diagnosis of gout as well as treatment and prevention of gout attacks.