Hallan and coauthors conducted an individual-level meta-analysis of 2 051 244 participants from 46 worldwide cohorts to evaluate effect modification by age of the association of eGFR and albuminuria with clinical risk of all-cause mortality and end-stage renal disease. In an editorial, de Boer discusses chronic kidney disease in older adults.
Friedman and coauthors estimate prevalence of nonrefractive visual impairment and describe its relationship with diabetes and other risk factors in 10 480 participants aged 20 years or older from NHANES 1999-2002 and 2005-2008. In an accompanying Editorial, Musch and Gardner discuss diabetes and nonrefractive visual impairment.
Traverse and coauthors for the Cardiovascular Cell Therapy Research Network report on the effect on left ventricular function of the use and timing of bone marrow mononuclear cell delivery after acute myocardial infarction. In an accompanying Editorial, Marbán and Malliaras discuss the mixed results for bone marrow–derived cell therapy for ischemic heart disease.
To test whether allogeneic mesenchymal stem cells (MSCs) are as safe and effective as autologous MSCs, Hare and coauthors injected 30 patients who had left ventricular dysfunction due to ischemic cardiomyopathy with stem cells by transendocardial stem cell injection. See the related Editorial by Marbán and Malliaras.
Latshang and coauthors evaluated whether acetazolamide combined with autoadjusted continuous positive airway pressure (autoCPAP) provides better oxygenation and control of sleep-related breathing disturbances than autoCPAP alone in 51 patients with obstructive sleep apnea syndrome spending a few days at moderate altitude.