Webber and coauthors performed a cross-sectional study to assess the prevalence of autopsy-determined atherosclerosis among 3832 US service members who died in support of Operations Enduring Freedom and Iraqi Freedom/New Dawn between October 2001 and August 2011. In an Editorial, Levy discusses the need to continue the national effort to preempt and prevent cardiovascular disease.
To assess the association between sustained virological response and all-cause mortality in patients with chronic hepatitis C virus infection and advanced hepatic fibrosis, van der Meer and coauthors assessed an interferon-based treatment regimen in 530 patients.
To improve reporting and interpretation of noninferiority and equivalence trials, Piaggio and coauthors present and discuss an updated extension of the CONSORT checklist based on the 2010 version of the CONSORT Statement and the 2008 CONSORT Statement for the reporting of abstracts.
Hamdan uses the case of Ms L, a patient with varicose veins, to review the causes, symptoms, evaluation, and treatment options for varicose vein management.
Noninferiority trials compare a novel treatment with the existing standard in order to determine if the new approach might lessen potential harms or burdens for the patient. In this Users’ Guide, Mulla and coauthors present a practical approach to interpreting these increasingly common studies.