To determine whether duloxetine can reduce pain experienced by patients with painful chemotherapy-induced peripheral neuropathy, Smith and coauthors conducted a randomized trial involving 231 patients who received either daily doses of 60 mg of duloxetine or placebo.
Fowler and coauthors conducted an international randomized trial among 8031 adult patients undergoing full median sternotomy to evaluate whether a novel vaccine candidate reduced the rate of serious postoperative Staphylococcus aureus infections. In an editorial, Malani discusses prevention of postoperative S aureus infections.
To evaluate trends in mortality for patients receiving care at critical access hospitals compared with non–critical access hospitals, Joynt and coauthors conducted a retrospective observational study using data from Medicare beneficiaries admitted to acute care hospitals between 2002 and 2010. Ioannidis provides comment in the related Editorial.
McMullan and coauthors report on melatonin secretion and the incidence of type 2 diabetes.
Using the case of a 74-year-old patient, Greene and coauthors discuss human immunodeficiency virus (HIV) in older patients, its screening and diagnosis, management of multiple concomitant diseases, social isolation, polypharmacy, and end-of-life care.