To determine if adding carotenoids and omega-3 fatty acids to the Age-Related Eye Disease Study (AREDS) formulation decreases risk of age-related macular degeneration (AMD) progression, 4203 patients in the AREDS2 trial at risk of developing advanced AMD were randomized to receive the AREDS formulation with lutein + zeaxanthin, docosahexaenoic acid + eicosapentaenoic acid, or both.
Nygaard and coauthors report long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse. In an accompanying Editorial, Iglesia discusses long-term outcomes after pelvic organ prolapse surgery and the implications for shared decision making.
To compare outcomes of single- and dual-chamber ICDs for primary prevention of sudden cardiac death, Peterson and coauthors analyzed registry data records of 32 034 patients who had received either 1 or 2 of the devices.
Because early diagnosis of glaucoma potentially prevents associated vision loss, Hollands and coauthors quantify the diagnostic accuracy of examination findings and relevant risk factors in identifying those with primary open-angle glaucoma in a Medline search of 41 population-based studies.