In a 2-year randomized trial involving 146 patients with symptomatic knee pain due to osteoarthritis, McAlindon and coauthors compared vitamin D supplementation with placebo to determine whether supplementation would reduce knee pain and increase cartilage volume.
Allen and coauthors performed a retrospective cohort study of culture-positive Neisseria gonorrhoeae infections at a single sexual health clinic in Toronto, Canada, to assess the risk of clinical treatment failure associated with the use of cefixime. In an Editorial, Kirkcaldy and coauthors describe the immediacy of the threat of drug-resistant gonorrhea.
Piazza discusses management of submassive pulmonary embolism, including diagnosis, prognosis, initial therapy, and long-term management, as exemplified by the case of Ms A, a 60-year-old woman with acute PE and right ventricular dysfunction.
To determine whether intravenous paracetamol would significantly (>30%) reduce morphine requirements in neonates and infants after major surgery, Ceelie and coauthors randomly assigned 71 infants younger than 1 year to receive paracetamol or morphine up to 48 hours following major surgery. Anand provides comment in the related Editorial.