In REDUCE (Reduction in the Use of Corticosteroids in Exacerbated COPD), a randomized, noninferiority multicenter trial, Leuppi and coauthors investigate whether a short-term systemic glucocorticoid treatment in patients with COPD exacerbation is noninferior to conventional treatment with respect to clinical outcome, and whether it decreases the exposure to steroids and reduces adverse effects. Sin discusses the study findings in an Editorial.
To determine whether the MUC5B promoter polymorphism is associated with survival in idiopathic pulmonary fibrosis, Peljto and coauthors conducted a retrospective study of survival in 2 independent cohorts of 438 and 148 patients each.
To compare the effect of controlling diabetes risk factors, Ikramuddin and colleagues compared a lifestyle and medical management protocol by assigning 60 of 120 mild to moderately obese patients with diabetes to undergo Roux-en-Y gastric bypass while participating in the protocol.
In a systematic review of 54 studies and reviews, Maggard-Gibbons and coauthors assess the association between bariatric surgery vs nonsurgical treatments, and weight loss and glycemic control among patients with diabetes or impaired glucose tolerance and body mass index of 30 to 35.
To highlight challenges clinicians face when interpreting small elevations of troponin levels in patients with clinical presentations that are not specific for acute coronary syndromes, de Lemos presents the case of a 62-year-old man with elevated troponin levels and discusses the multiple non-ACS etiologies that might account for those elevated levels.