Edelmann and coauthors conducted a randomized controlled trial among 422 patients with heart failure with preserved ejection fraction to assess whether spironolactone is superior to placebo in improving diastolic function and maximal exercise capacity.
Dimick and coauthors report on the complications following bariatric surgery before vs after implementation of a national policy restricting coverage to centers of excellence. In an accompanying Editorial, Greenberg discusses promoting quality surgical care.
Johnson and coauthors studied the US incidence of advanced breast cancer among women using data from the Surveillance, Epidemiology, and End Results (SEER) database from 1976 through 2009. They analyzed breast cancer incidence, incidence trends, and survival rates as a function of age and extent of disease at diagnosis.
Time intervals between surveillance scans used to determine growth of small abdominal aortic aneurysms prior to rupture are studied by Bown and colleagues in an individual patient data meta-analysis of 15 471 patients.
Calvert and colleagues expand the Consolidated Standards of Reporting Trials (CONSORT) to include 5 guidelines essential for adequately reporting patientreported outcomes as primary or major secondary end points in research articles in its CONSORT PRO guidelines.