Editor's Audio Summary by Edward H. Livingston, MD, Deputy Editor, the Journal of the American Medical Association, for the October 09, 2013 issue
Boughey and coauthors determine the false-negative rate for sentinel lymph node (SLN) surgery following chemotherapy in 663 women initially presenting with biopsy-proven node-positive breast cancer. In an Editorial, Morrow and Dang discuss false-negative rates and their role in determining whether to use more aggressive therapies.
To determine risk factors for adverse cardiac events in patients undergoing noncardiac surgery after coronary stent implantation, Hawn and coauthors conducted a national, retrospective cohort study of 41 989 operations occurring within 2 years of stent placement. In an Editorial, Brilakis and Banerjee discuss the approach clinicians can take with patients who need surgery after receiving stents.
To analyze whether previously reported improvement in disease-free survival with adjuvant gemcitabine therapy translates into improved overall survival, Oettle and coauthors conducted a multicenter, open-label, phase 3 randomized trial to evaluate the efficacy and toxicity of gemcitabine in patients with pancreatic cancer after complete tumor resection.
To examine whether hospital surveillance bias influences the validity of reported venous thromboembolism (VTE) rates, Bilimoria and coauthors examined Medicare data for beneficiaries undergoing select major operations. Livingston comments in a related Editorial.
Manning reviews the current the development, progression, and assessment of aortic stenosis, discusses the appropriate monitoring intervals for transthoracic echocardiography, and outlines the indications for valve procedures.