Editor's Audio Summary by Derek C. Angus, MD, MPH, Associate Editor, the Journal of the American Medical Association, for the October 23/30, 2013 issue
To determine whether statin therapy can decrease day-28 mortality in patients with VAP, Papazian
and coauthors conducted a randomized, placebo-controlled, double-blind, parallel-group, multicenter
trial in 26 intensive care units in France from January 2010 to March 2013.
In the AWARE randomized clinical trial, Metsch and coauthors assessed the effect of brief patient-centered risk-reduction counseling at the time of a rapid HIV test on the subsequent acquisition of sexually transmitted infections. In an Editorial, Haukoos and Thrun discuss the elimination of prevention counseling from HIV screening.
Dr Udell and coauthors determine if influenza vaccination is associated with prevention of cardiovascular events from randomized clinical trials comparing influenza vaccine vs placebo or control in high-risk cardiovascular patients. In an Editorial, Neuzil discusses the trial limitations in establishing the level of protection of a vaccine from the perspective of public health and offers proven methods to increase vaccination coverage for the 2013-2014 influenza season.
To determine whether treating critically ill patients with severe septic shock with esmolol, a
short-acting β-blocker, to reduce their heart rates, Morelli and coauthors conducted an
open-label, randomized phase 2 study, involving 154 qualifying patients treated at a university
hospital intensive care unit.
To examine the diagnosis, management, and treatment of conjunctivitis, Azari and Barney conducted a literature review of articles on both infectious and noninfectious conjunctivitis.