Editor's Audio Summary by Mary McGrae McDermott, MD, Senior Editor, the Journal of the American Medical Association, for the April 02, 2014 issue
In a randomized trial testing the efficacy of tadalafil with radiotherapy to treat prostate cancer, Pisansky and coauthors found that compared with placebo, 24 weeks of tadalafil daily did not result in in improved spontaneous, off-drug erectile function.
Kaukonen and coauthors describe changes in mortality from 2000 to 2012 for severe sepsis with and without shock in 101 064 patients in 171 intensive care units in Australia and New Zealand. In an Editorial, Iwashyna and Angus discuss the challenge of determining changes in the epidemiology of severe sepsis and evaluating improvements in quality of care.
Rohde and coauthors evaluate whether red blood cell (RBC) transfusion thresholds are associated with the risk of infection and whether risk is independent of leukocyte reduction in this meta-analysis of 17 trials.
Walter and Schonberg perform a review of peer-reviewed journals to identify risk factors for breast cancer in older women and to quantify the benefits and harms of screening mammography for women aged 75 years and older.