Numerous prospective studies have demonstrated that reduced high-density lipoprotein cholesterol (HDL-C) and elevated triglyceride (TG) levels, but not low-density lipoprotein cholesterol levels (LDL-C),1- 4 are independent risk factors that are associated with type 2 diabetes (T2D). However, causal evaluation based on these studies is limited owing to the potential for unmeasured confounding and reverse causality. Hence, the relevance of each of these lipoprotein fractions in association with T2D is actively debated.
Saleheen D, Rader DJ, Voight BF. Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics. JAMA Cardiol. 2016;1(6):631–633. doi:10.1001/jamacardio.2016.2298