The Dual Antiplatelet Therapy (DAPT) Study1 was an international, blinded, placebo-controlled, randomized trial comparing 2 durations of thienopyridine therapy to prevent stent thrombosis (ST) or the composite end point of mortality, myocardial infarction (MI), or stroke among 9961 patients treated with drug-eluting stents. The study aimed to demonstrate that prolonged thienopyridine therapy (ie, for an additional 18 months) would be noninferior to standard therapy duration (ie, 1-year therapy after coronary stenting) with respect to moderate or severe bleeding as defined by the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) classification.1 A secondary cohort consisting of 1687 patients treated with bare metal stents was also included.
Valgimigli M, Gargiulo G. Deciding on the Duration of Dual Antiplatelet Therapy—When the Choice Between 2 Evils Is Still Evil. JAMA Cardiol. Published online March 15, 2017. doi:10.1001/jamacardio.2017.0125