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Comment & Response
June 7, 2017

Increased Cardiovascular Risk Associated With E-Cigarette Use—Reply

Author Affiliations
  • 1Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
  • 2Department of Environmental Health Sciences, School of Public Health, Los Angeles, California
JAMA Cardiol. Published online June 7, 2017. doi:10.1001/jamacardio.2017.1766

In Reply We thank Sanchis-Gomar et al for their interest in our work.1 These authors make the interesting, even provocative, suggestion that perhaps the reported differences in sympathetic tone and the susceptibility to oxidative stress are not actually due to an increase in sympathetic tone and oxidative stress in e-cigarette users but rather due to a reduction in these variables in nonusers attributable to greater physical activity.

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