To the Editor We read the article by Ho et al1 with great interest. The authors shed light on the concept of genotypic and phenotypic classification of complex heterogeneous cardiovascular diseases (CVDs), such as hypertrophic cardiomyopathy (HCM). The study found that mutation carriers without left ventricular hypertrophy had altered cardiac dimensions and function and a higher percentage of early phenotypes than observed in healthy control individuals.1 The implication is that phenotype alone may not adequately detect early pathophysiologic changes of HCM and that a combined genotypic and phenotypic approach may be needed, as the association is not always linear.
Krittanawong C, Kitai T. Identifying Genotypes and Phenotypes of Cardiovascular Diseases Using Big Data Analytics. JAMA Cardiol. Published online June 14, 2017. doi:10.1001/jamacardio.2017.1857