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July 2011

Double-Headed Nodules on the Abdomen —Diagnosis

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; SENAIT W. DYSON, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD

Arch Dermatol. 2011;147(7):857-862. doi:10.1001/archdermatol.2011.163-b

Histologic findings revealed monomorphous spindle-shaped cells with abundant mucinous extracellular components proliferating throughout the dermis underlying a normal epidermis. The spindle-shaped cells were strongly positive for CD34 and negative for S-100, Factor XIIIa and α-SMA. The mucinous component of the lesion stained strongly with Alcian blue. Genetic analysis of the tumor revealed an abnormal chimeric fusion transcription in which exon 43 of the gene encoding collagen type 1 alpha 1 (COL1A1) was translocated into exon 2 of the gene encoding platelet-derived growth factor beta chain (PDGFB) (Figure 3). A total resection of the tumor was performed with no adjuvant therapy. No recurrence was seen a 1-year follow-up.

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