Author Affiliations: Department of Dermatology, Hospital Cl ínic, Universitat de Barcelona, Spain.
Sarcoidosis is a multisystemic disorder characterized by noncaseating granulomas made up of macrophages and T cells. Isolated extrapulmonary disease has been reported in 10% of cases.1 We present a rare case of isolated tongue involvement that responded to cyclosporine.
A 46-year-old healthy woman presented with tender lesions in her tongue of 2 years' duration. She denied a history of smoking, trauma, amalgams, or piercings. Examination revealed several firm nodules on the dorsal aspect of her tongue (Figure 1). A punch biopsy specimen showed well-defined, noncaseating epithelioid granulomas affecting the submucosal and muscular layers (Figure 2). Foreign material was not identified. Findings of analysis with special stains and fungal and mycobacterial cultures were negative. The tuberculin skin test result was negative.
Guilabert A, Mu ñoz-Santos C, Aguilera P, Mascar ó JÉM, Ferrando J. Isolated Sarcoidal Granulomas on the Tongue. Arch Dermatol. 2011;147(8):989–991. doi:10.1001/archdermatol.2011.211