Author Affiliations: Division of Dermatopathology, Mount Sinai School of Medicine, New York, New York.
The histiocytoses are a group of rare diseases that represent a proliferation of dendritic cells or macrophages. We describe a patient who presented with a cutaneous-limited histiocytosis with histologic features of indeterminate cell histiocytosis that uniquely failed to express S-100.
A 79-year-old white man presented with multiple erythematous nonpruritic papules on his chest, abdomen, upper arms, and back (Figure 1). The eruption, present for approximately 6 months, had failed to respond to high-dose steroids prescribed by a previous dermatologist. Our initial impression was of a contact dermatitis or other eczematous reaction.
Ventarola DJ, Mercer SE, Contard PC, Odaimi MF, Emanuel PO, Birge MB, Phelps RG. S-100 –Negative, CD1a-Positive Histiocytosis: A New Variant With Features of Both Indeterminate Cells and Interstitial Dermal Dendrocytes. Arch Dermatol. 2011;147(8):995-997. doi:10.1001/archdermatol.2011.219