Author Affiliations: Department of Dermatology, Venereology, and Allergology, St Josef Hospital (Dr Kreuter) and Department of Internal Medicine, University Clinic Bergmannsheil (Dr Meyer), Ruhr-University Bochum, Bochum, Germany (Dr Meyer); Institute of Virology, National Reference Center for Papilloma- and Polyomaviruses, University of Cologne, Cologne, Germany (Dr Wieland).
Biological therapies targeting tumor necrosis factor (TNF) have become increasingly used agents in the fields of dermatology and rheumatology. It is well known that TNF inhibitors may increase the susceptibility for bacterial and mycobacterial disease. In contrast, the risk of viral infections under treatment with TNF inhibitors is less well appreciated.1 We herein report on the development of multifocal penile intraepithelial neoplasia (PIN) following anti-TNF therapy with adalimumab.
Kreuter A, Meyer MF, Wieland U. Occurrence of Penile Intraepithelial Neoplasia Following Adalimumab Treatment for Psoriatic Arthritis. Arch Dermatol. 2011;147(8):1001-1002. doi:10.1001/archdermatol.2011.218